“Metabolism of Cell Death and its Ramifications for Therapeutics and Drug Development”
Conference location: National University of Singapore, Singapore
June 29-July 1, 2012
Organizers:
Shazib
Pervaiz, Richard Lockshin, and Zahra Zakeri
Friday June 29th 12:00pm – 5:00pm:
Welcome Introduction and awards
Chair: Zahra Zakeri, Dept. of Biology, Queens College of CUNY, USA
12:00-12:15pm Introduction and welcome
Zahra Zakeri: Queens College, U.S.A.
12:15-12:45pm Presenting Award to Dr. Kimchi
Richard A. Lockshin: St. Johns University, U.S.A
12:45-1:45pm Programmed cell death: from single gene studies towards global network analysis
Adi Kimchi: Weizmann Inst., Israel
1:45-2:15pm The hows and whys of IAPs as revealed by multi-gene deletions and SMAC-mimetics
David Vaux: WEHI Institute and LaTrobe University, Australia
2:15-2:30pm Coffee
2:30-3:00pm Regulation of apoptosis
signaling by the outer mitochondrial membrane protein MOAP-1 and Bax-beta
Victor C Yu: National
University of Singapore, Singapore
3:00-3:30pm BID
stimulates the ATR-directed DNA damage response to replicative stress to
maintain hematopoietic stem and progenitor cell function- insights into
maintenance of hematopoietic stem cell function in aging organisms
Sandra Zinkel: Vanderbilt University School of Medicine, USA
3:30-4:00pm Exposure of phosphatidylserine to the cell surface
Shigekazu Nagata: Kyoto University, Japan
4:00-4:30 pm TAM Receptors Control Phagocytosis of Apoptotic
Cells
Raymond Birge: Univ. Med. Dent. New Jersey, USA
4:30-4:45 pm Activation of Lysosomal Function in the Course of Autophagy via mTORC1 Suppression and Autophagosome-Lysosome Fusion
Han-Ming Shen, National University of
Singapore
4:45-5:00pm Novel function and age-dependent changes of the ubiquitin system in selective autophagy
Esther Wong Nanyang Technological University, Singapore
Saturday June 30th 9:00am –5:PM
Cell death Metabolism: Redox and Energetics
Chair: Simone Fulda: Univ. of Ulm, Germany
9:00-9:30am intracellular redox status and cell fate regulation by
the Bcl-2 family
Shazib Pervaiz: National
University of Singapore, Singapore
9:30-10:00am Metabolic vulnerabilities and cancer cell death.
David Hockenbery Fred Huntchinson Cancer Research Center USA
10:00-10:30am Ongogene driven redox cell survival mechanisms'
Thomas G Cotter University College Cork Ireland
10:30-11:00am Coffee Break
11:00-11:30am Effect of ceramide depletion on cellular bioenergetics, survival, and autophagy
Scott A. Summers: Duke-National University of Singapore, Singapore
11:30-11:45am XF Mito Stress Test reveals metabolic dysfunctions underlying cellular degeneration and guides translational studies”
David A. Ferrick: Chief Scientific Officer, Seahorse Bioscience
11:45- 12:00pm Identification of gamma-tocotrienol as a novel chemosensitizer in xenograft mouse model of human gastric cancer
Gautam Sethi National University of Singapore, Singapore
12:00-2:00pm Lunch and poster presentation and WORKSHOP OF INDUSTRY OR TRANSLATIONAL IMPLICATION
Chair: Marianne J Cronje: Univ. Johannesburg, South Africa
2:00-2:30pm Revisiting the pathways activated upon the induction of intracellular redox imbalance and their role in tumorigenesis and tumor cells’ resistance to chemotherapy
Marie-Veronique Clement: National University of Singapore, Singapore
2:30-3:00pm Unfolding the role of ROS-mediated ER stress in immunogenic apoptosis of cancer cells
Patrizia Agostinis: University of Leuven Belgium
3:00- 3:30pm Targeting IAP proteins for tumor cell
sensitization to cell death
Simone Fulda: Univ.
of Ulm, Germany
3:30-5:00pm Coffee: and WORKSHOP ON BUILDING A CAREER IN SCIENCE : Panel Discussion on Tactics for Junior Scientists and Women. Panelists Patrizia Agostinis, Marie-Veronique Clement; Adi Kimchi; Sandra Zinkel, Ana Maria Cuervo, Devrim Gozuacik, Boris Zhivotovsky, Simone Fulda
Saturday July 1 th 9:00am – 5:00pm
Role of autophagy & apoptosis in metabolic health and aging
Chair: Raymond Birge: Univ. Med. Dent. New Jersey, USA Chair:
9:00-9:30am Discovery of new autophagy regulators
Devrim Gozuacik: Sabanci University, Turkey
9:30-10:00am Selective autophagy in aging and age-related pathologies
Ana Maria Cuervo, Einstein Medical College, USA
10:00-10:15am Secreted frizzled-related protein 4 expression is positively associated with responsiveness to cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers.
Arun Dharmarajan, The University of Western Australia, Western Australia
10:15-10:30am Age-dependent relationships between reactive oxygen species and hsp70 in human neutrophils under cell stress conditions.
Kovalenko E.I., - Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia
10:30-11:00am Coffee Break
Chair: Nader Maghsoudi: Shahid Beheshti University, Iran
11:00-11:30am Inhibition of prenyl protein carboxylmethylation induces autophagic cell death
Mei Wang: National University of Singapore, Singapore
11:30-12:00am Lung cancer: mechanisms of resistance and sensitivity to treatment.
Boris Zhivotovsky: Karolinska Institute, Sweden
12:00-2:00pm Lunch and Posters and WORKSHOP OF INDUSTRY OR TRANSLATIONAL IMPLICATION (2nd round)
Chair: Shazib Pervaiz: National University of Singapore, Singapore
2:00-2:30pm The serendipitous discovery of the selective apoptotic-inducing abilities of novel metal phosphine compounds in cancer cells
Marianne J Cronje, Univ. Johannesburg, South Africa
2:30-3:00pm Regulation of cellular survival by p53 and p73 – implications for cancer therapy
Kanaga Sabapathy: National University of Singapore, Singapore
3:00--3:30pm Future
Anti-Cancer Therapeutic Targets: Putting the Carts Before the Horses?
Tak Mak, Advanced Medical
Discovery Unit, University of Toronto, Canada
3:30-4:00pm Coffee
4:00-4:30pm Therapeutic targeting Myc dependency in cancer cells: new pathway implicated in tumorigenesis and targeted therapy.
Yu Qiang: National University of Singapore, Singapore
4:30-4:45pm The
mechanism by which a novel palladacycle aj-5 exerts its anti-tumour activity in
breast cancer cells involves apoptosis and autophagy
Aliwaini S*
University of Cape Town.
4:45-5:00pm Closing remarks: Zahra Zakeri