Maynooth Announcement

The Fifth International Cell Death

Richard Lockshin -1416414211

 

The Fifth International Cell Death

Society Symposium

Maynooth, Ireland 2004

 

Friday 25th June 2004

 

Time                                              Session, Topic

 

11:00 am-7:00 pm                        Delegate Registration (HumeBuilding, North Campus)

 

*****

I. Welcome and Introduction

 

2:00-2:30pm                                 Zahra Zakeri

                                                      Queens College, City University of New York, U.S.A. 

 

II. Modulators of cell death and cell survival

Chair: Junying Yuan

 

2:30-3:00 pm                                Chemical Definition of a Novel Cell Death Pathway
Junying Yuan:
Harvard Medical School, U.S.A.

 

3:00-3:30 pm                                Bad integrates glycolysis & apoptosis through a mitochodrial macromolecular complex with glucokinase

                                                      Nika Danial: Howard Hughes Medical Institute, U.S.A 

 

3:30-4:00 pm                                Role of the BH3-Only protein BIM in diseases

                                                      Philippe Bouillet: WEHI, Australia

 

4:00-4:30pm                                 Effectors and inhibitors of Bcl-2 family proteins on mitochondria and the ER

                                                      Christoph Borner: Institute of Molecular Medicine& Cell Research, Germany 

 

4:30-5:00pm                                 Coffee

 

5:00-5:30pm                                 IGF-1 survival signaling in tumor cells

                                                      Rosemary O’Connor: National University of Ireland, Ireland 

 

5:30-6:00pm                                 Bax-induced calcium release and wave propagation in cell death

                                                      Soraya Smaili: Federal University of Sao Paulo, Brazil.

 

6:00-6:20pm                                 LEDGF: a novel modulator of cell death and survival in the face of stress

                                                      Carlos Casiano: Loma Linda University School of Medicine, U.S.A. 

 

6:20-6:40                                      The roles of BID in apoptosis

                                                      Atan Gross: Weizmann Institute, Israel 

 

7:00pm-10:00pm                          Welcome reception (hot buffet, Pugin Hall)

 

Saturday 26th June 2004

 

III. Paths to destruction—Receptor driven pathways

Chair: Roya Khosravi-Far

 

9:00-9:30am                                 Studies from Fas to the engulfment of apoptotic cells

                                                      Shigekazu Nagata: Osaka University Medical School, Japan.

 

9:30-10:00am                               CD95 (Apo-1/FAS) signaling pathways and diseases

                                                      Peter Krammer: German Cancer Research Center, Germany

 

10:00-10:30am                             TRAIL-induced signaling and apoptosis

                                                      Marion Macfarlane: University of Leicester, U.K

 

10:30-10:50am                             The Mer tyrosine kinase (Mertk) provides ‘enhancing signals’ for abb5-integrin-mediated phagocytosis of apoptotic cells
Raymond Birge: UMDNJ-New Jersey Medical School, U.S.A

 

10:50-11:20am                             Coffee

 

11:20-11:50am                             The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

                                                      Jurg Tschopp: University of Lausanne, Switzerland:

 

11:50-12:20                                  Molecular switches and spatial control of cell death in neurons

                                                      Pierluigi Nicotera: University of Leicester, U.K

 

12:20-12:50am                             Mechanisms controlling sensitivity and resistance to TRAIL.

                                                      Henning Walczak: German Cancer Research Center, Germany

 

12:50-1:10pm 40pm                     Regulation of divergent cell death pathways by Bcr-Abl

                                                      Gustavo Amarante-Mendes: University of Sao Paulo, Brazil

 

12:40-1:1000pm                           Mechanisms controlling sensitivity and resistance to TRAIL.

                                                      Henning Walczak: German Cancer Research Center, Germany 

 

1:00-2:15pm                                 Lunch

 

*****

 

IV. Paths to destruction—Intracellular Pathways

Chair: Michael Hengartner

 

2:15-2:45pm                                 Cell death pathways in cancer

                                                      Yuri Lazebnik: Cold Spring Harbor Laboratory, U.S.A 

 

2:45-3:15pm                                 The dual role of Omi/HtrA2 in survival and death

                                                      Emad AlnemriThomas Jefferson Univ., U.S.A.

 

3:15-3:45pm                                 Monitoring mitochondrial and post-mitochondrial death signals in real time

                                                      Jochen Prehn: Royal College of Surgeons in Ireland, Ireland 

 

3:45-4:15pm                                 Coffee

 

4:15-4:45pm                                 Bcl-Xl can repair apoptotic permeability of the mitochondrial outer membrane in vitro

                                                      Ruth Kluck: Walter & Eliza Hall Institute of Medical Research, Australia 

 

4:45-5:05pm                                 Die another way!

                                                      Afshin Samali: National University of Ireland, Ireland

 

5:05-5:25pm                                 The BH3 domain protein BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes

                                                      Lorie Kirshenbaum: University of Manitoba, Canada

 

5:30-pm                                         Poster session

 

7:30pm                                          Dinner (Pugin Hall, South Campus) followed by Social Event.

 

Sunday 27th June 2004

 

V. Agents of destruction (caspases, cathepsins, granzymes)

Chair: Raymond Birge

 

9:00-9:30am                                 Cellular and therapeutic aspects of caspase modulation

                                                      Don Nicholson: Merck Research Laboratories, U.S.A

 

9:30-10:00am                Transcriptional Regulation of Caspase activation in  Drosophila
                           Sharad Kumar: Hanson Institute, Australia 
 

10:00-10:30am                             Granzyme A directly triggers mitochondrial damage (without apoptogenic factor release) that is necessary for apoptosis induction

                                                      Judy Lieberman: The CBR Inst. For Biomedical Research, Harvard Medical School, U.S.A

 

10:30-11:00am                             Coffee

 

11:00-11:30am                             Identification of novel substrates of the CTL/NK protease Granzyme

                                                      Seamus Martin:  Trinity College Dublin, Ireland 

 

11:30-12:00am                             Caspase activation inhibits proteasome function during apoptosis
Gerry Cohen:
University of Leicester, U.K

 

12:00-12:30am                             Expanding roles for the apoptosome in development and diseases

                                                      Francesco Cecconi: University of Rome “Tor Vergata”, Italy

 

12:30-1:00pm                               Lysosomal control of tumor cell death

                                                      Marja Jättellä: Institute of CancerBiology, Denmark

 

1:00-2:30pm                                 Lunch

 

VI. Sensing and Responding to Damage

Chair: Hans-Uwe Simon

 

2:30-3:00pm                                 Molecular networks in programmed cell death: DAP genes and beyond

                                                      Adi Kimchi: Weizmann Institute, Israel 

 

3:00-3:30pm                                 BRCA1- A differential modulator of chemotherapy induced apoptosis

                                                      Paul Harkin: Belfast City Hospital, N. Ireland

 

3:30-3:50pm                                 Actin cytoskeleton network as a modulator of apoptosis and phagocytic activity in metastatic melanoma cells

                                                      Walter Malorni: Istituto Superiore di Sanita, Italy

 

3:50-4:20pm                                 Coffee

 

4:20-4:50pm                                 Regulating the apoptotic function of p53 by the ASPP family of proteins

                                                      Xin Lu: ImperialCollegeLondon, England

 

4:50-5:20pm                                 Cell Cycle Proteins in the Neuronal response to Neurodegenerative Stimuli

                                                      Kelly Jordan: University of Pennsylvania School of Dentistry, U.S.A. 

 

5:20-pm                                         Poster session

 

7:30pm                                          Meeting Dinner (Pugin Hall) Introductory Presentation Richard A. Lockshin

                                                      Honoring Prof. Krammer and Prof. Nagata

 

Monday 28th June 2004

 

VII. Apoptosis in Action (Animal models, Immunity & Disease)

Chair: Amedeo Colombano

 

9:00-9:30am                                 Cell death in the eye: A model for disease and development  

                                                      Tom Cotter: University College Cork, Ireland 

 

9:30-10:00am                               Regulation of death ligand-induced apoptosis in immunopathology

                                                      Thomi Brunner: University of Bern, Switzerland

 

10:00-10:30am                             Transglutaminase 2 regulates the mitochondrial respiratory complexes assembly in vivo through its protein disulphide isomerase activity

                                                      Mauro Piacentini: University of Rome “Tor Vergata”, Italy

 

10:30-10:50am                             Modulation of prostate tumor cells response to radiation

                                                      Adrianna Haimovitz-Friedman: Memorial Sloan Kettering Cancer Center, USA 

 

10:50-11:20am                             Coffee

 

11:20-11:50am                             The NOD family of proteins: Role in innate immunity and inflammatory disease

                                                      Gabriel Nuñez: University of Michigan Medical School, USA 

 

11:50-12:10am                             Presence of functional extrinsic and intrinsic apoptotic pathways in human mesenchymal stem cells 

                                                      Huseyin Mehmet: Imperial College London Hammersmith Hospital Campus, U.K 

 

12:10-12:30am                             Identification of proteins regulating p73 function     Vincenzo De Laurenzi: MRC Toxicology Unit, U.K

 

12:30-1:00pm                               Wrap-Up

                                                      Boris Zhivotovsky: Karolinska Institutet, Sweden 

 

1:00-2:15pm                                 Lunch and End of Meeting