Ireland 2004; Peter Krammer

In 1989, Peter Krammer began to give lectures in which, using spectacular pictures, he described a molecule that could cause even huge mouse tumors of hematopoietic origin to completely disappear. Quickly recognizing how it worked, he called the molecule APO-1, which he described in a paper in Science: Monoclonal antibody-mediated tumor regression by induction of apoptosis. Trauth BC, Klas C, Peters AM, Matzku S, Möller P, Falk W, Debatin KM, Krammer PH. Science. 1989 245:301-5.

The molecule proved to be an already-known molecule, CD95, also being explored as Fas for its role in autoimmune disease, but Krammer’s results put him in the forefront of the exploration of the role of apoptosis in cancer, a vast field in which he and his laboratory have made and continue to make major contributions, at theoretical, research, and clinical levels, and his laboratory has produced a new generation of outstanding researchers.