Member Publications

Immunogenic cell death and its therapeutic or prognostic potential in high-grade glioma.
Decraene B, Yang Y, De Smet F, Garg AD, Agostinis P, et al.
Genes Immun 2022 Jan 19

USP15 and USP4 facilitate lung cancer cell proliferation by regulating the alternative splicing of SRSF1.
Das T, Lee EY, You HJ, Kim EE, Song EJ, et al.
Cell Death Discov 2022 Jan 13

Neoadjuvant programmed cell death 1 blockade combined with chemotherapy for resectable esophageal squamous cell carcinoma.
Yang W, Xing X, Yeung SJ, Wang S, Chen W, et al.
J Immunother Cancer 2022 Jan

Neurokinin-1 receptor promotes non-small cell lung cancer progression through transactivation of EGFR.
Zhang XW, Li L, Hu WQ, Hu MN, Tao Y, et al.
Cell Death Dis 2022 Jan 10

TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex.
Airiau K, Vacher P, Micheau O, Prouzet-Mauleon V, Kroemer G, et al.
Cells 2021 Dec 25

Microsatellite Instability, Epstein-Barr Virus, and Programmed Cell Death Ligand 1 as Predictive Markers for Immunotherapy in Gastric Cancer.
Yu HY, Li CP, Huang YH, Hsu SJ, Wang YP, et al.
Cancers (Basel) 2022 Jan 3

SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics.
Ramachandran K, Maity S, Muthukumar AR, Kandala S, Tomar D, et al.
iScience 2022 Jan 21

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological Strategies.
Muñoz-Córdova F, Hernández-Fuentes C, Lopez-Crisosto C, Troncoso MF, Calle X, et al.
Front Cardiovasc Med 2021

Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes.
Yoon S, Bogdanov K, Wallach D
Cell Death Differ 2022 Jan 9

L-Cysteine capped zinc oxide nanoparticles induced cellular response on adenocarcinomic human alveolar basal epithelial cells using a conventional and organ-on-a-chip approach.
A A, X J, V A, P V M
Colloids Surf B Biointerfaces 2021 Dec 28

MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.
Lim JM, Lee R, Kim Y, Lee IY, Kim E, et al.
Cell Mol Life Sci 2021 Dec 30

Role of Damage-Associated Molecular Pattern/Cell Death Pathways in Vaccine-Induced Immunity.
Lee SM, Kim P, You J, Kim EH
Viruses 2021 Nov 23

Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System.
Abbas R, Larisch S
Cells 2021 Dec 8

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid.
Merhi F, Alvarez-Valadez K, Trepiana J, Lescoat C, Groppi A, et al.
Cells 2021 Nov 30

Polyhexamethylene guanidine phosphate increases stress granule formation in human 3D lung organoids under respiratory syncytial virus infection.
Choi S, Choi S, Choi Y, Cho N, Kim SY, et al.
Ecotoxicol Environ Saf 2022 Jan 1

Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction.
Parker E, Aboghazleh R, Mumby G, Veksler R, Ofer J, et al.
Brain 2021 Dec 20

Comparing EGFR tyrosine kinase inhibitor treatments in EGFR-mutated non-small cell lung cancer across Asian and non-Asian patients: a plain language summary.
Kim E
Future Oncol 2021 Dec 17

ABT-737, a BH3 Mimetic, Enhances the Therapeutic Effects of Ionizing Radiation in K-ras Mutant Non-Small Cell Lung Cancer Preclinical Model.
Lee JM, Kim HS, Kim A, Chang YS, Lee JG, et al.
Yonsei Med J 2022 Jan

GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.
Yu H, Yang W, Huang J, Miao X, Wang B, et al.
Cell Death Dis 2021 Dec 16

Oxygen-Deficient BiOCl Combined with L-Buthionine-Sulfoximine Synergistically Suppresses Tumor Growth through Enhanced Singlet Oxygen Generation under Ultrasound Irradiation.
Wang H, Yang W, Bian K, Zeng W, Jin X, et al.
Small 2021 Dec 15

Combinatorial immunotherapy induces tumor-infiltrating CD8⁺ T cells with distinct functional, migratory, and stem-like properties.
Van Braeckel-Budimir N, Dolina JS, Wei J, Wang X, Chen SH, et al.
J Immunother Cancer 2021 Dec

Immunogenic ferroptosis and where to find it?
Demuynck R, Efimova I, Naessens F, Krysko DV
J Immunother Cancer 2021 Dec

The evolution of regulated cell death pathways in animals and their evasion by pathogens.
Tummers B, Green DR
Physiol Rev 2022 Jan 1

Comparative immunogenicity and effectiveness of mRNA-1273, BNT162b2 and Ad26.COV2.S COVID-19 vaccines.
Naranbhai V, Garcia-Beltran WF, Chang CC, Mairena CB, Thierauf JC, et al.
J Infect Dis 2021 Dec 9

Treatment of Acute Graft-versus-Host Disease in Liver Transplant Recipients.
Kim E, Adeel A, Bozorgzadeh A, Amano S, Barry CT, et al.
Case Rep Transplant 2021

The power of genetic diversity in genome-wide association studies of lipids.
Graham SE, Clarke SL, Wu KH, Kanoni S, Zajac GJM, et al.
Nature 2021 Dec

Neonatal sepsis-causing bacterial pathogens and outcome of trends of their antimicrobial susceptibility a 20-year period at a neonatal intensive care unit.
Song WS, Park HW, Oh MY, Jo JY, Kim CY, et al.
Clin Exp Pediatr 2021 Dec 9

Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
Yang W, Tao K, Zhang P, Chen X, Sun X, et al.
Biochem Pharmacol 2022 Jan

A Phase I/IIa Randomized Trial Evaluating the Safety and Efficacy of SNK01 Plus Pembrolizumab in Patients with Stage IV Non-Small Cell Lung Cancer.
Kim EJ, Cho YH, Kim DH, Ko DH, Do EJ, et al.
Cancer Res Treat 2021 Dec 3

Extracellular and Intracellular Skeletons: How Do They Involve in Apoptosis.
Ni JH, Yang WX
DNA Cell Biol 2021 Nov 26

COVID-19 pandemic dynamics in India, the SARS-CoV-2 Delta variant, and implications for vaccination.
Yang W, Shaman J
medRxiv 2021 Nov 22

MICU3 regulates mitochondrial Ca²⁺-dependent antioxidant response in skeletal muscle aging.
Yang YF, Yang W, Liao ZY, Wu YX, Fan Z, et al.
Cell Death Dis 2021 Nov 29

Prognostic impact of neutrophilia and lymphopenia on survival in anal cancer treated with definitive concurrent chemoradiotherapy: a retrospective multicenter study.
Kim E, Kim TH, Jung W, Kim K, Chang AR, et al.
Int J Clin Oncol 2021 Nov 29

Temporary Upregulation of Nrf2 by Naringenin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells.
Chen W, Ye Y, Wu Z, Lin J, Wang Y, et al.
Oxid Med Cell Longev 2021

TRAIL sensitivity of nasopharyngeal cancer cells involves redox dependent upregulation of TMTC2 and its interaction with membrane caspase-3.
Raman D, Tay P, Hirpara JL, Liu D, Pervaiz S, et al.
Redox Biol 2021 Nov 20

Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation.
Woo SM, Seo SU, Min KJ, Kwon TK
J Pineal Res 2022 Jan

Precise control over the silica shell thickness and finding the optimal thickness for the peak heat diffusion property of AuNR@SiO₂.
Yang W, Kaur S, Kim YD, Kim JM, Lee SH, et al.
J Mater Chem B 2022 Jan 19

Mitochondria-targeted accumulation of oxygen-irrelevant free radicals for enhanced synergistic low-temperature photothermal and thermodynamic therapy.
Hu H, Deng X, Song Q, Yang W, Zhang Y, et al.
J Nanobiotechnology 2021 Nov 25

Dying cells fan the flames of inflammation.
Newton K, Dixit VM, Kayagaki N
Science 2021 Nov 26

Exercise Reverses Amyloid Beta-Peptide-mediated Cognitive Deficits in Alzheimer's Disease Mice Expressing Mutant Presenilin-2.
Hwang DJ, Choi DH, Kwon KC, Kim EH, Kim TK, et al.
Med Sci Sports Exerc 2021 Nov 23

Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis.
Tzeng HE, Lin SL, Thadevoos LA, Lien MY, Yang WH, et al.
Cell Death Dis 2021 Nov 23

Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer.
Sprooten J, Vankerckhoven A, Vanmeerbeek I, Borras DM, Berckmans Y, et al.
J Immunother Cancer 2021 Nov

Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo.
Seo SU, Woo SM, Kim S, Park JW, Lee HS, et al.
Oncogene 2021 Nov 16

Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Liao W, Yang W, Xu J, Yan Z, Pan M, et al.
Front Pharmacol 2021

A GLP-1/GLP-2 receptor dual agonist to treat NASH: Targeting the gut-liver axis and microbiome.
Kim ER, Park JS, Kim JH, Oh JY, Oh IJ, et al.
Hepatology 2021 Nov 12

Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death.
Bock FJ, Sedov E, Koren E, Koessinger AL, Cloix C, et al.
Nat Commun 2021 Nov 12

FLLL32 Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells by Regulating the p38 Pathway.
Su CW, Chuang CY, Chen YT, Yang WE, Pan YP, et al.
Int J Mol Sci 2021 Nov 1

Omega-3 Polyunsaturated Fatty Acid Attenuates Uremia-Induced Brain Damage in Mice.
Kim EJ, Ham YR, Shin JA, Jeong JY, Na KR, et al.
Int J Mol Sci 2021 Oct 30

Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model.
Aboghazleh R, Parker E, Yang LT, Kaufer D, Dreier JP, et al.
Int J Mol Sci 2021 Oct 28

Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1.
Pihán P, Lisbona F, Borgonovo J, Edwards-Jorquera S, Nunes-Hasler P, et al.
Sci Adv 2021 Nov 12

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells.
Lenoir WF, Morgado M, DeWeirdt PC, McLaughlin M, Griffith AL, et al.
Nat Commun 2021 Nov 11

T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
Chun N, Ang RL, Chan M, Fairchild RL, Baldwin WM 3rd, et al.
JCI Insight 2021 Dec 22

The integrated stress response in ischemic diseases.
Zhang G, Wang X, Rothermel BA, Lavandero S, Wang ZV, et al.
Cell Death Differ 2021 Nov 6

A gene toolbox for monitoring autophagy transcription.
Bordi M, De Cegli R, Testa B, Nixon RA, Ballabio A, et al.
Cell Death Dis 2021 Nov 2

Immune checkpoint blockade in the treatment of malignant tumor: current statue and future strategies.
Yang W, Lei C, Song S, Jing W, Jin C, et al.
Cancer Cell Int 2021 Nov 2

Revealing the metabolic mechanism of dandelion extract against A549 cells using UPLC-QTOF MS.
Man J, Wu L, Han P, Hao Y, Li J, et al.
Biomed Chromatogr 2021 Nov 2

Tumorigenesis and cell competition in Drosophila in the absence of polyhomeotic function.
Medina I, Calleja M, Morata G
Proc Natl Acad Sci U S A 2021 Nov 9

Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis.
Zhang T, Zhang G, Yang W, Chen H, Hu J, et al.
Cell Death Dis 2021 Oct 25

[6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway.
Zhang H, Kim E, Yi J, Hai H, Kim H, et al.
In Vivo 2021 Nov-Dec

Comparative immunogenicity and effectiveness of mRNA-1273, BNT162b2 and Ad26.COV2.S COVID-19 vaccines.
Naranbhai V, Garcia-Beltran WF, Chang CC, Mairena CB, Thierauf JC, et al.
medRxiv 2021 Oct 13

Balancing life and death: BCL-2 family members at diverse ER-mitochondrial contact sites.
Means RE, Katz SG
FEBS J 2021 Oct 20

β-Hydroxybutyrate Exacerbates Hypoxic Injury by Inhibiting HIF-1α-Dependent Glycolysis in Cardiomyocytes-Adding Fuel to the Fire?
Ma X, Dong Z, Liu J, Ma L, Sun X, et al.
Cardiovasc Drugs Ther 2021 Oct 15

Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes.
Hwang JS, Kim E, Lee HG, Lee WJ, Won JP, et al.
Biomed Pharmacother 2021 Nov

c-Jun N-terminal kinase (JNK) in Procambarus clarkii: Molecular characterization and involvement in oxidative stress-induced apoptosis during molting cycle.
Tian H, Yuning W, Yang W, Liu F, Yu Y, et al.
Comp Biochem Physiol B Biochem Mol Biol 2022 Jan

Simvastatin induced ferroptosis for triple-negative breast cancer therapy.
Yao X, Xie R, Cao Y, Tang J, Men Y, et al.
J Nanobiotechnology 2021 Oct 9

How vitamin E and its derivatives regulate tumour cells via the MAPK signalling pathway?'
Yu ZQ, Wang LM, Yang WX
Gene 2022 Jan 15

Stem cells from exfoliated deciduous teeth transplantation ameliorates Sjögren's syndrome by secreting soluble PD-L1.
Yang N, Liu X, Chen X, Yu S, Yang W, et al.
J Leukoc Biol 2021 Oct 8

Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID.
Clough E, Inigo J, Chandra D, Chaves L, Reynolds JL, et al.
J Neuroimmune Pharmacol 2021 Dec

Hsa_circ_0011385 knockdown represses cell proliferation in hepatocellular carcinoma.
Ni C, Yang S, Ji Y, Duan Y, Yang W, et al.
Cell Death Discov 2021 Oct 1

Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity.
Chen SH, Dominik PK, Stanfield J, Ding S, Yang W, et al.
J Immunother Cancer 2021 Oct

Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and β-Catenin Signaling.
Wang N, Wang Y, Wang H, Luo N, Yang W, et al.
DNA Cell Biol 2021 Oct

D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner.
Zhou X, Zheng Y, Sun W, Zhang Z, Liu J, et al.
Cell Prolif 2021 Nov

Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.
Kuo TF, Hsu SW, Huang SH, Chang CL, Feng CS, et al.
EMBO Mol Med 2021 Oct 7

BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9 transcription.
Jiang HS, Ghose P, Han HF, Wu YZ, Tsai YY, et al.
Development 2021 Oct 15

Y-2 reduces oxidative stress and inflammation and improves neurological function of collagenase-induced intracerebral hemorrhage rats.
Hua Y, Zhou L, Yang W, An W, Kou X, et al.
Eur J Pharmacol 2021 Nov 5

Carbamylated erythropoietin improves recognition memory by modulating microglia in a rat model of pain.
Rahmani N, Mohammadi M, Manaheji H, Maghsoudi N, Katinger H, et al.
Behav Brain Res 2022 Jan 7

Docosahexaenoic acid monoglyceride induces apoptosis and autophagy in breast cancer cells via lipid peroxidation-mediated endoplasmic reticulum stress.
Wang TT, Yang Y, Wang F, Yang WG, Zhang JJ, et al.
J Food Sci 2021 Oct

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.
Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, et al.
Cell Host Microbe 2021 Oct 13

Phase II Study of Pembrolizumab in Combination with Doxorubicin in Metastatic and Unresectable Soft-Tissue Sarcoma.
Livingston MB, Jagosky MH, Robinson MM, Ahrens WA, Benbow JH, et al.
Clin Cancer Res 2021 Dec 1

Understanding the Link Between Obesity and Severe COVID-19 Outcomes: Causal Mediation by Systemic Inflammatory Response.
Foulkes AS, Selvaggi C, Shinnick D, Lumish H, Kim E, et al.
J Clin Endocrinol Metab 2022 Jan 18

Autophagy in major human diseases.
Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, et al.
EMBO J 2021 Oct 1

Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting.
Rufo N, Korovesis D, Van Eygen S, Derua R, Garg AD, et al.
Cell Death Differ 2022 Jan

Isolation, characterization and HepG-2 inhibition of a novel proteoglycan from Flammulina velutipes.
Xu H, Hu Y, Hu Q, Liu J, Su A, et al.
Int J Biol Macromol 2021 Oct 31

The lysosome as a master regulator of iron metabolism.
Rizzollo F, More S, Vangheluwe P, Agostinis P
Trends Biochem Sci 2021 Dec

IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death.
Wang P, Yang W, Guo H, Dong HP, Guo YY, et al.
Adv Sci (Weinh) 2021 Oct

Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats.
Zhu K, Zhu X, Sun S, Yang W, Liu S, et al.
Exp Neurol 2021 Nov

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death.
A Z, J SW, A M, E L, I W, et al.
Cell Tissue Res 2021 Oct

Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Rabinovich-Nikitin I, Rasouli M, Reitz CJ, Posen I, Margulets V, et al.
Autophagy 2021 Nov

Low PDCD4 Expression Is Associated With Poor Prognosis of Colorectal Carcinoma.
Kim JY, Lee H, Kim EK, Lee WM, Hong YO, et al.
Appl Immunohistochem Mol Morphol 2021 Oct 1

MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma.
Liu H, Chi Z, Jin H, Yang W
Bioengineered 2021 Dec

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Wu W, Wang X, Sun Y, Berleth N, Deitersen J, et al.
Autophagy 2021 Dec

Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, et al.
Autophagy 2021 Nov

Apoptotic effect of jaceosidin on MCF-7 human breast cancer cells through modulation of ERK and p38 MAPK pathways.
Ojulari OV, Chae JB, Lee SG, Min K, Kwon TK, et al.
Nat Prod Res 2021 Dec