Member Publications

Caspase-8 deficiency in mouse embryos triggers chronic RIPK1-dependent activation of inflammatory genes, independently of RIPK3.
Kang TB, Jeong JS, Yang SH, Kovalenko A, Wallach D, et al.
Cell Death Differ 2018 Apr 17

PRMT1 negatively regulates activation-induced cell death in macrophages by arginine methylation of GAPDH.
Cho JH, Lee R, Kim E, Choi YE, Choi EJ, et al.
Exp Cell Res 2018 Apr 14

Regulation of the antiapoptotic protein cFLIP by the glucocorticoid Dexamethasone in ALL cells.
Kleinesudeik L, Rohde K, Fulda S
Oncotarget 2018 Mar 27

Correction: The B cell death function of obinutuzumab-HDEL produced in plant (Nicotiana benthamiana L.) is equivalent to obinutuzumab produced in CHO cells.
Lee JW, Heo W, Lee J, Jin N, Yoon SM, et al.
PLoS One 2018

Clinical implication of programmed death-ligand 1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition.
Kwon MJ, Rho YS, Nam ES, Cho SJ, Park HR, et al.
Hum Pathol 2018 Apr 7

Taurine prevents ethanol-induced apoptosis mediated by mitochondrial or death receptor pathways in liver cells.
Wu G, Yang J, Lv H, Jing W, Zhou J, et al.
Amino Acids 2018 Apr 6

A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease.
Yan S, Tu Z, Liu Z, Fan N, Yang H, et al.
Cell 2018 Mar 23

The mechanism study of lentiviral vector carrying methioninase enhances the sensitivity of drug-resistant gastric cancer cells to Cisplatin.
Xin L, Yang WF, Zhang HT, Li YF, Liu C, et al.
Br J Cancer 2018 Mar 26

Prognostic implication of programmed cell death 1 protein and its ligand expressions in endometrial cancer.
Kim J, Kim S, Lee HS, Yang W, Cho H, et al.
Gynecol Oncol 2018 Mar 20

The in vitro effects of a novel estradiol analog on cell proliferation and morphology in human epithelial cervical carcinoma.
Boyd LS, Gozuacik D, Joubert AM
Cell Mol Biol Lett 2018

Differential expression patterns of the short and long isoform of cFLIP on FasL‑mediated apoptosis.
Um HJ, Chauhan AK, Min KJ, Kwon TK
Oncol Rep 2018 May

Hydroquinone Exhibits In Vitro and In Vivo Anti-Cancer Activity in Cancer Cells and Mice.
Byeon SE, Yi YS, Lee J, Yang WS, Kim JH, et al.
Int J Mol Sci 2018 Mar 19

EFF-1 fusogen promotes phagosome sealing during cell process clearance in Caenorhabditis elegans.
Ghose P, Rashid A, Insley P, Trivedi M, Shah P, et al.
Nat Cell Biol 2018 Apr

Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
Lee CJ, Moon SJ, Jeong JH, Lee S, Lee MH, et al.
Cell Death Dis 2018 Mar 14

Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-induced apoptosis through upregulation of Bim expression.
Seo SU, Woo SM, Min KJ, Kwon TK
Biochem Biophys Res Commun 2018 Apr 15

BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression.
Woo SM, Seo SU, Min KJ, Kwon TK
Cell Death Discov 2018 Dec

Receptor-Interacting Protein Kinases 1 and 3, and Mixed Lineage Kinase Domain-Like Protein Are Activated by Sublytic Complement and Participate in Complement-Dependent Cytotoxicity.
Lusthaus M, Mazkereth N, Donin N, Fishelson Z
Front Immunol 2018

Protective effect of rutin against carbon tetrachloride-induced oxidative stress, inflammation and apoptosis in mouse kidney associated with the ceramide, MAPKs, p53 and calpain activities.
Ma JQ, Liu CM, Yang W
Chem Biol Interact 2018 Apr 25

The Application of Embelin for Cancer Prevention and Therapy.
Ko JH, Lee SG, Yang WM, Um JY, Sethi G, et al.
Molecules 2018 Mar 9

Hypoxia and the Prolyl Hydroxylase Inhibitor FG-4592 Protect Corneal Endothelial Cells From Mechanical and Perioperative Surgical Stress.
Bhadange Y, Lautert J, Li S, Lawando E, Kim ET, et al.
Cornea 2018 Apr

Targeting autophagy for the treatment of cancer.
Fulda S
Biol Chem 2018 Apr 6

Phenytoin inhibits necroptosis.
von Mässenhausen A, Tonnus W, Himmerkus N, Parmentier S, Saleh D, et al.
Cell Death Dis 2018 Mar 2

DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/β-catenin pathway via GSK3β.
Liu XF, Li XY, Zheng PS, Yang WT
Cell Death Dis 2018 Mar 1

Ophiopogonin D modulates multiple oncogenic signaling pathways, leading to suppression of proliferation and chemosensitization of human lung cancer cells.
Lee JH, Kim C, Lee SG, Yang WM, Um JY, et al.
Phytomedicine 2018 Feb 1

Knockdown of end-binding protein 1 induces apoptosis in radioresistant A549 lung cancer cells via p38 kinase-dependent COX-2 upregulation.
Baek JH, Yim JH, Song JY, Um HD, Park JK, et al.
Oncol Rep 2018 Apr

Circulating Plasma Cells at the Time of Collection of Autologous PBSC for Transplant in Multiple Myeloma Patients is a Negative Prognostic Factor Even in the Age of Post-Transplant Maintenance Therapy.
Cowan AJ, Stevenson PA, Libby EN, Becker PS, Coffey DG, et al.
Biol Blood Marrow Transplant 2018 Mar 1

Treatment-related mortality in newly diagnosed pediatric cancer: a population-based analysis.
Gibson P, Pole JD, Lazor T, Johnston D, Portwine C, et al.
Cancer Med 2018 Mar

Repurposing anticancer drugs for targeting necroptosis.
Fulda S
Cell Cycle 2018 Feb 21

Inhibition of IAP's and activation of p53 leads to caspase-dependent apoptosis in gastric cancer cells treated with Scutellarein.
Gowda Saralamma VV, Lee HJ, Raha S, Lee WS, Kim EH, et al.
Oncotarget 2018 Jan 19

Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy.
Choi SR, Lim JH, Kim MY, Kim EN, Kim Y, et al.
Metabolism 2018 Feb 17

Mitochondrial Dysfunctions Contribute to Hypertrophic Cardiomyopathy in Patient iPSC-Derived Cardiomyocytes with MT-RNR2 Mutation.
Li S, Pan H, Tan C, Sun Y, Song Y, et al.
Stem Cell Reports 2018 Mar 13

Cinacalcet-mediated activation of the CaMKKβ-LKB1-AMPK pathway attenuates diabetic nephropathy in db/db mice by modulation of apoptosis and autophagy.
Lim JH, Kim HW, Kim MY, Kim TW, Kim EN, et al.
Cell Death Dis 2018 Feb 15

Effect of Mst1 on Endometriosis Apoptosis and Migration: Role of Drp1-Related Mitochondrial Fission and Parkin-Required Mitophagy.
Zhao Q, Ye M, Yang W, Wang M, Li M, et al.
Cell Physiol Biochem 2018

There are only four basic modes of cell death, although there are many ad-hoc variants adapted to different situations.
Liu X, Yang W, Guan Z, Yu W, Fan B, et al.
Cell Biosci 2018

The ability of silver(I) thiocyanate 4-methoxyphenyl phosphine to induce apoptotic cell death in esophageal cancer cells is correlated to mitochondrial perturbations.
Engelbrecht Z, Meijboom R, Cronjé MJ
Biometals 2018 Apr

Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway.
Khan NA, Garg AD, Agostinis P, Swinnen JV
Oncotarget 2018 Jan 9

Smac mimetic induces an early wave of gene expression via NF-κB and AP-1 and a second wave via TNFR1 signaling.
Schmidt N, Haydn T, Schneider I, Busch H, Boerries M, et al.
Cancer Lett 2018 May 1

Noninvasive whole-body imaging of phosphatidylethanolamine as a cell death marker using ^99mTc-duramycin during TNF-induced SIRS.
Delvaeye T, Wyffels L, Deleye S, Lemeire K, Gonçalves A, et al.
J Nucl Med 2018 Feb 1

Fryl deficiency is associated with defective kidney development and function in mice.
Byun YS, Kim EK, Araki K, Yamamura KI, Lee K, et al.
Exp Biol Med (Maywood) 2018 Mar

Apoptosis and Clearance of Apoptotic Cells.
Nagata S
Annu Rev Immunol 2018 Apr 26

Autophagy is essential for the maintenance of amino acids and ATP levels during acute amino acid starvation in MDAMB231 cells.
Thomas M, Davis T, Loos B, Sishi B, Huisamen B, et al.
Cell Biochem Funct 2018 Mar

Cooperation between Hsp90 and mortalin/GRP75 in resistance to cell death induced by complement C5b-9.
Rozenberg P, Ziporen L, Gancz D, Saar-Ray M, Fishelson Z, et al.
Cell Death Dis 2018 Feb 2

MEHP promotes the proliferation of cervical cancer via GPER mediated activation of Akt.
Yang W, Tan W, Zheng J, Zhang B, Li H, et al.
Eur J Pharmacol 2018 Apr 5

PAX8 activates a p53-p21-dependent pro-proliferative effect in high grade serous ovarian carcinoma.
Ghannam-Shahbari D, Jacob E, Kakun RR, Wasserman T, Korsensky L, et al.
Oncogene 2018 Jan 30

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy.
Schaaf MB, Garg AD, Agostinis P
Cell Death Dis 2018 Jan 25

Cell death-based treatment of glioblastoma.
Fulda S
Cell Death Dis 2018 Jan 25

miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis.
Kang W, Huang T, Zhou Y, Zhang J, Lung RWM, et al.
Cell Death Dis 2018 Jan 24

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, et al.
Cell Death Differ 2018 Mar

Protective Effect of BLED-exposed Conditioned Media on Cell Injury.
Oh PS, Kim EM, Kim M, Kim IS, Han YH, et al.
Photochem Photobiol 2018 Jan 19

Photoaging protective effects of BIOGF1K, a compound-K-rich fraction prepared from <i>Panax ginseng</i>.
Hong YH, Kim D, Nam G, Yoo S, Han SY, et al.
J Ginseng Res 2018 Jan

A matter of life and death: stem cell survival in tissue regeneration and tumour formation.
Soteriou D, Fuchs Y
Nat Rev Cancer 2018 Mar

Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition.
Serasinghe MN, Gelles JD, Li K, Zhao L, Abbate F, et al.
Cell Death Dis 2018 Jan 18

TIPE2 suppresses progression and tumorigenesis of esophageal carcinoma via inhibition of the Wnt/β-catenin pathway.
Zhu L, Zhang X, Fu X, Li Z, Sun Z, et al.
J Transl Med 2018 Jan 17

The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content.
Shaikh S, Troncoso R, Mondaca-Ruff D, Parra V, Garcia L, et al.
Toxicol In Vitro 2018 Apr

Mouse lung fibroblasts are highly susceptible to necroptosis in a reactive oxygen species-dependent manner.
Hussain M, Zimmermann V, van Wijk SJL, Fulda S
Biochem Pharmacol 2018 Jan 11

The B cell death function of obinutuzumab-HDEL produced in plant (Nicotiana benthamiana L.) is equivalent to obinutuzumab produced in CHO cells.
Lee JW, Heo W, Lee J, Jin N, Yoon SM, et al.
PLoS One 2018

Immunomodulation characteristics by thermal ablation therapy in cancer patients.
Yang W, Wang W, Liu B, Zhu B, Li J, et al.
Asia Pac J Clin Oncol 2018 Jan 8

MiR-93-5p up-regulation is involved in non-small cell lung cancer cells proliferation and migration and poor prognosis.
Yang W, Bai J, Liu D, Wang S, Zhao N, et al.
Gene 2018 Mar 20

Cross Talk Between Cellular Redox State and the Antiapoptotic Protein Bcl-2.
Pohl SÖ, Agostino M, Dharmarajan A, Pervaiz S
Antioxid Redox Signal 2018 Feb 15

Heterogeneity of PD-L1 expression in primary tumors and paired lymph node metastases of triple negative breast cancer.
Li M, Li A, Zhou S, Xu Y, Xiao Y, et al.
BMC Cancer 2018 Jan 2

ZEB1 stimulates breast cancer growth by up-regulating hTERT expression.
Yu P, Shen X, Yang W, Zhang Y, Liu C, et al.
Biochem Biophys Res Commun 2018 Jan 22

Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin β1/ Src signaling in triple negative breast cancer cells.
Hamurcu Z, Delibaşı N, Geçene S, Şener EF, Dönmez-Altuntaş H, et al.
J Cancer Res Clin Oncol 2018 Mar

Correction for Gyrd-Hansen et al., "Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9".
Gyrd-Hansen M, Farkas T, Fehrenbacher N, Bastholm L, Høyer-Hansen M, et al.
Mol Cell Biol 2018 Jan 15

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.
Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, et al.
Cell Death Differ 2018 Mar

The M458L missense mutation disrupts the catalytic properties of Parkin.
Do YJ, Yun SY, Park MY, Kim E
FEBS Lett 2018 Jan

microRNA-137 promotes endothelial progenitor cell proliferation and angiogenesis in cerebral ischemic stroke mice by targeting NR4A2 through the Notch pathway.
Liu XL, Wang G, Song W, Yang WX, Hua J, et al.
J Cell Physiol 2018 Jul

A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer.
Cevatemre B, Erkısa M, Aztopal N, Karakas D, Alper P, et al.
Pharmacol Res 2018 Mar

Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison.
Chong SJF, Lai JXH, Eu JQ, Bellot GL, Pervaiz S, et al.
Antioxid Redox Signal 2018 Jan 9

DLP1-dependent mitochondrial fragmentation and redistribution mediate prion-associated mitochondrial dysfunction and neuronal death.
Li C, Wang D, Wu W, Yang W, Ali Shah SZ, et al.
Aging Cell 2018 Feb

ASIC2a overexpression enhances the protective effect of PcTx1 and APETx2 against acidosis-induced articular chondrocyte apoptosis and cytotoxicity.
Zhou RP, Ni WL, Dai BB, Wu XS, Wang ZS, et al.
Gene 2018 Feb 5

Near infrared dye-conjugated oxidative stress amplifying polymer micelles for dual imaging and synergistic anticancer phototherapy.
Yang W, Noh J, Park H, Gwon S, Singh B, et al.
Biomaterials 2018 Feb

Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells.
Kumar S, Inigo JR, Kumar R, Chaudhary AK, O'Malley J, et al.
Cancer Lett 2018 Jan 28

Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response.
Hombach-Klonisch S, Mehrpour M, Shojaei S, Harlos C, Pitz M, et al.
Pharmacol Ther 2018 Apr

MOMP, cell suicide as a BCL-2 family business.
Kalkavan H, Green DR
Cell Death Differ 2018 Jan

Angelicin potentiates TRAIL-induced apoptosis in renal carcinoma Caki cells through activation of caspase 3 and down-regulation of c-FLIP expression.
Min KJ, Um HJ, Seo SU, Woo SM, Kim S, et al.
Drug Dev Res 2018 Feb

Feasibility study on the use of gold nanoparticles in fractionated kilovoltage X-ray treatment of melanoma.
Kim SR, Kim EH
Int J Radiat Biol 2018 Jan

Kinase-independent role of nuclear RIPK1 in regulating parthanatos through physical interaction with PARP1 upon oxidative stress.
Jang KH, Jang T, Son E, Choi S, Kim E, et al.
Biochim Biophys Acta 2018 Jan

BCL-x_L-selective BH3 mimetic sensitizes rhabdomyosarcoma cells to chemotherapeutics by activation of the mitochondrial pathway of apoptosis.
Faqar-Uz-Zaman SF, Heinicke U, Meister MT, Vogler M, Fulda S, et al.
Cancer Lett 2018 Jan 1

Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.
Geric I, Tyurina YY, Krysko O, Krysko DV, De Schryver E, et al.
Immunology 2018 Mar

Eruptive keratoacanthomas arising in the setting of lichenoid toxicity after programmed cell death 1 inhibition with nivolumab.
Feldstein SI, Patel F, Larsen L, Kim E, Hwang S, et al.
J Eur Acad Dermatol Venereol 2018 Feb

Exosomal miR-9-3p suppresses HBGF-5 expression and is a functional biomarker in hepatocellular carcinoma.
Tang J, Li Y, Liu K, Zhu Q, Yang WH, et al.
Minerva Med 2018 Feb

Human immunology studies using organ donors: Impact of clinical variations on immune parameters in tissues and circulation.
Carpenter DJ, Granot T, Matsuoka N, Senda T, Kumar BV, et al.
Am J Transplant 2018 Jan

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.
Teufelberger AR, Nordengrün M, Braun H, Maes T, De Grove K, et al.
J Allergy Clin Immunol 2018 Feb

Mitochondria-Associated Membranes and ER Stress.
van Vliet AR, Agostinis P
Curr Top Microbiol Immunol 2018