Member Publications

Smac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress.
Abhari BA, McCarthy N, Le Berre M, Kilcoyne M, Joshi L, et al.
Cell Death Dis 2019 Feb 15

PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway.
Baek JH, Yun HS, Kwon GT, Lee J, Kim JY, et al.
Cell Death Dis 2019 Feb 15

Cytochrome c-deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer.
Kumar R, Bhat TA, Walsh EM, Chaudhary AK, O'Malley J, et al.
Cancer Res 2019 Feb 14

Cathepsins: Potent regulators in carcinogenesis.
Khaket TP, Kwon TK, Kang SC
Pharmacol Ther 2019 Feb 11

Modulation of the ATM/autophagy pathway by a G-quadruplex ligand tips the balance between senescence and apoptosis in cancer cells.
Beauvarlet J, Bensadoun P, Darbo E, Labrunie G, Rousseau B, et al.
Nucleic Acids Res 2019 Feb 13

Endoplasmic reticulum stress and NLRP3 inflammasome: Crosstalk in cardiovascular and metabolic disorders.
Ji T, Han Y, Yang W, Xu B, Sun M, et al.
J Cell Physiol 2019 Feb 11

TAZ stimulates liver regeneration through interleukin-6-induced hepatocyte proliferation and inhibition of cell death after liver injury.
Kim AR, Park JI, Oh HT, Kim KM, Hwang JH, et al.
FASEB J 2019 Feb 11

Circadian-Regulated Cell Death in Cardiovascular Diseases.
Rabinovich-Nikitin I, Lieberman B, Martino TA, Kirshenbaum LA
Circulation 2019 Feb 12

Cell cycle arrest in mitosis promotes interferon-induced necroptosis.
Frank T, Tuppi M, Hugle M, Dötsch V, van Wijk SJL, et al.
Cell Death Differ 2019 Feb 11

Author Correction: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.
Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, et al.
Cell Death Differ 2019 Feb 11

Interview: a conversation with Vishva M Dixit on his journey from remote African village to apoptosis, necroptosis and the inflammasome.
Dixit VM
Cell Death Differ 2019 Feb 8

Staying in touch: Taking a closer look at ER-Golgi contact sites.
Sassano ML, Agostinis P
J Cell Biol 2019 Feb 7

Cationic amino acid transporter PQLC2 is a potential therapeutic target in gastric cancer.
Jeung YJ, Lee K, Lee HJ, Kim E, Son MJ, et al.
Cancer Sci 2019 Feb 6

Pilose Antler Extracts (PAEs) Protect against Neurodegeneration in 6-OHDA-Induced Parkinson's Disease Rat Models.
Li C, Sun Y, Yang W, Ma S, Zhang L, et al.
Evid Based Complement Alternat Med 2019

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications.
Nazio F, Bordi M, Cianfanelli V, Locatelli F, Cecconi F, et al.
Cell Death Differ 2019 Feb 6

Incorporation of circulating tumor cells and whole-body metabolic tumor volume of ¹⁸F-FDG PET/CT improves prediction of outcome in IIIB stage small-cell lung cancer.
Fu L, Zhu Y, Jing W, Guo D, Kong L, et al.
Chin J Cancer Res 2018 Dec

Autophagy in endothelial cells and tumor angiogenesis.
Schaaf MB, Houbaert D, Meçe O, Agostinis P
Cell Death Differ 2019 Jan 28

NF-κB contributes to Smac mimetic-conferred protection from tunicamycin-induced apoptosis.
Abhari BA, McCarthy N, Agostinis P, Fulda S
Apoptosis 2019 Jan 24

Stearate-Induced Apoptosis in Human Pancreatic β-Cells is Associated with Changes in Membrane Protein Expression and These Changes are Inhibited by Oleate.
Němcová-Fürstová V, Balušíková K, Halada P, Pavlíková N, Šrámek J, et al.
Proteomics Clin Appl 2019 Jan 21

Targeting intrinsic cell death pathways to control fungal pathogens.
Kulkarni M, Stolp ZD, Hardwick JM
Biochem Pharmacol 2019 Jan 17

Correction: BNIP3 modulates the interface between B16-F10 melanoma cells and immune cells.
Romano E, Rufo N, Korf H, Mathieu C, Garg AD, et al.
Oncotarget 2018 Dec 11

Human Leukocyte Antigen Class I and Programmed Death-Ligand 1 Co-expression Is an Independent Poor Prognostic Factor in Adenocarcinoma of the Lung.
Han YB, Kwon HJ, Park SY, Kim ES, Kim H, et al.
J Pathol Transl Med 2019 Jan 14

Paroxetine Induces Apoptosis of Human Breast Cancer MCF-7 Cells through Ca²⁺-and p38 MAP Kinase-Dependent ROS Generation.
Cho YW, Kim EJ, Nyiramana MM, Shin EJ, Jin H, et al.
Cancers (Basel) 2019 Jan 9

Bone metastases and skeletal-related events: incidence and prognosis according to histological subtype of lung cancer.
Silva GT, Silva LM, Bergmann A, Thuler LC
Future Oncol 2019 Feb

Accurate elimination of superfluous attachment cells is critical for the construction of functional multicellular proprioceptors in Drosophila.
Avetisyan A, Salzberg A
Cell Death Differ 2019 Jan 8

The Cell-Death-Associated Polymer PAR Feeds Forward α-Synuclein Toxicity in Parkinson's Disease.
Donyo M, Ashkenazi A
Mol Cell 2019 Jan 3

JAK2 regulation by licochalcone H inhibits the cell growth and induces apoptosis in oral squamous cell carcinoma.
Oh HN, Oh KB, Lee MH, Seo JH, Kim E, et al.
Phytomedicine 2019 Jan

Spontaneous Cancers, But Not Many Induced Ones in Animals, Resemble Semi-New Organisms that Possess a Unique Programmed Cell Death Mode Different from Apoptosis, Senescent Death, Necrosis and Stress-Induced Cell Death.
Shi M, Zhou H, Lei M, Chen L, Zellmer L, et al.
J Cancer 2018

An Effective Two Way Classification of Breast Cancer Images: A Detailed Review
P S, M M
Asian Pac J Cancer Prev 2018 Dec 25

PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome.
Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, et al.
Proc Natl Acad Sci U S A 2019 Jan 2

Non-coding RNAs regulating cardiac muscle mass.
Wadley GD, Lamon S, Alexander SE, McMullen JR, Bernardo BC, et al.
J Appl Physiol (1985) 2018 Dec 20

Heavy metal rich stone-processing wastewater inhibits the growth and development of plants.
Hong L, Zhang L, Liu M, Wang S, He L, et al.
Int J Phytoremediation 2018 Dec 18

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.
Tron AE, Belmonte MA, Adam A, Aquila BM, Boise LH, et al.
Nat Commun 2018 Dec 17

Interferon-alpha promotes immunosuppression through IFNAR1/STAT1 signalling in head and neck squamous cell carcinoma.
Ma H, Yang W, Zhang L, Liu S, Zhao M, et al.
Br J Cancer 2019 Feb

Programmed death ligand-1 is associated with tumor infiltrating lymphocytes and poorer survival in urothelial cell carcinoma of the bladder.
Wang B, Pan W, Yang M, Yang W, He W, et al.
Cancer Sci 2019 Feb

Amelioration of amyloid β-FcγRIIb neurotoxicity and tau pathologies by targeting LYN.
Gwon Y, Kim SH, Kim HT, Kam TI, Park J, et al.
FASEB J 2018 Dec 12

Glucose deprivation promotes apoptotic response to S1 by enhancing autophagy in human cervical cancer cells.
Zhou L, Kong Q, Zhang Y, Yang W, Yan S, et al.
Cancer Manag Res 2018

Overview of BCL-2 Family Proteins and Therapeutic Potentials.
Huska JD, Lamb HM, Hardwick JM
Methods Mol Biol 2019

Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos.
Lee WS, Cho HJ, Kim E, Huh YH, Kim HJ, et al.
Nanoscale 2019 Feb 14

An emerging role for nanomaterials in increasing immunogenicity of cancer cell death.
Mishchenko T, Mitroshina E, Balalaeva I, Krysko O, Vedunova M, et al.
Biochim Biophys Acta Rev Cancer 2019 Jan

Interferons Transcriptionally Up-Regulate MLKL Expression in Cancer Cells.
Knuth AK, Rösler S, Schenk B, Kowald L, van Wijk SJL, et al.
Neoplasia 2019 Jan

Casticin inhibits growth and enhances ionizing radiation-induced apoptosis through the suppression of STAT3 signaling cascade.
Lee JH, Kim C, Ko JH, Jung YY, Jung SH, et al.
J Cell Biochem 2018 Dec 5

The natural polyphenol curcumin induces apoptosis by suppressing STAT3 signaling in esophageal squamous cell carcinoma.
Liu Y, Wang X, Zeng S, Zhang X, Zhao J, et al.
J Exp Clin Cancer Res 2018 Dec 5

To the edge of cell death and back.
Gong YN, Crawford JC, Heckmann BL, Green DR
FEBS J 2019 Feb

Up-regulation of P-gp via NF-κB activation confers protection against oxidative damage in the retinal pigment epithelium cells.
Feng Q, Yang W, Gao Z, Ruan X, Zhang Y, et al.
Exp Eye Res 2018 Nov 26

TBK1 and IKKε restrain cell death.
Heger K, Dixit VM
Nat Cell Biol 2018 Dec

Identification of 5-(2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine Derivatives as a New Class of Receptor-Interacting Protein Kinase 1 (RIPK1) Inhibitors, Which Showed Potent Activity in a Tumor Metastasis Model.
Li Y, Xiong Y, Zhang G, Zhang L, Yang W, et al.
J Med Chem 2018 Nov 27

Calcimimetic restores diabetic peripheral neuropathy by ameliorating apoptosis and improving autophagy.
Chung YC, Lim JH, Oh HM, Kim HW, Kim MY, et al.
Cell Death Dis 2018 Nov 26

Functional Biological Activity of Sorafenib as a Tumor-Treating Field Sensitizer for Glioblastoma Therapy.
Jo Y, Kim EH, Sai S, Kim JS, Cho JM, et al.
Int J Mol Sci 2018 Nov 21

Prolonged MEK inhibition leads to acquired resistance and increased invasiveness in KRAS mutant gastric cancer.
Choi KM, Cho E, Kim E, Shin JH, Kang M, et al.
Biochem Biophys Res Commun 2018 Dec 9

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP.
Jeon MY, Min KJ, Woo SM, Seo SU, Choi YH, et al.
Molecules 2018 Nov 20

Nanoparticles induce apoptosis via mediating diverse cellular pathways.
Chen L, Wu LY, Yang WX
Nanomedicine (Lond) 2018 Nov

Gene Therapy in Head and Neck Cancer.
Farmer ZL, Kim ES, Carrizosa DR
Oral Maxillofac Surg Clin North Am 2019 Feb

Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases.
Duvigneau JC, Luís A, Gorman AM, Samali A, Kaltenecker D, et al.
Cytokine 2018 Nov 14

Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers.
Chen W, Yang W, Chen P, Huang Y, Li F, et al.
ACS Appl Mater Interfaces 2018 Nov 16

Ribosomal protein S6 kinase 1 promotes the survival of photoreceptors in retinitis pigmentosa.
Lin B, Xiong G, Yang W
Cell Death Dis 2018 Nov 15

PLOD3 promotes lung metastasis via regulation of STAT3.
Baek JH, Yun HS, Kwon GT, Kim JY, Lee CW, et al.
Cell Death Dis 2018 Nov 15

Increased incidence, morbidity and mortality rates for lung cancer in women in Brazil between 2000 and 2014: An analysis of three types of sources of secondary data.
Costa GJ, de Mello MJG, Ferreira CG, Bergmann A, Thuler LCS, et al.
Lung Cancer 2018 Nov

The prognostic role of PD-L1 expression for survival in head and neck squamous cell carcinoma: A systematic review and meta-analysis.
Yang WF, Wong MCM, Thomson PJ, Li KY, Su YX, et al.
Oral Oncol 2018 Nov

Differential involvement of TAK1, RIPK1 and NF-κB signaling in Smac mimetic-induced cell death in breast cancer cells.
Schmidt N, Kowald L, van Wijk SJL, Fulda S
Biol Chem 2019 Jan 28

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Koren E, Yosefzon Y, Ankawa R, Soteriou D, Jacob A, et al.
Nat Commun 2018 Nov 2

Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.
Moon S, Im SK, Kim N, Youn H, Park UH, et al.
Cell Death Dis 2018 Nov 2

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during <i>Yersinia</i> infection.
Sarhan J, Liu BC, Muendlein HI, Li P, Nilson R, et al.
Proc Natl Acad Sci U S A 2018 Nov 13

EUS-guided irreversible electroporation using endoscopic needle-electrode in porcine pancreas.
Lee JM, Choi HS, Chun HJ, Kim ES, Keum B, et al.
Surg Endosc 2019 Feb

C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells.
Byun HS, Zhou W, Park I, Kang K, Lee SR, et al.
Biochem Pharmacol 2018 Dec

Programmed Necrosis and Disease:We interrupt your regular programming to bring you necroinflammation.
Kim EH, Wong SW, Martinez J
Cell Death Differ 2019 Jan

Crashing the computer: apoptosis vs. necroptosis in neuroinflammation.
Heckmann BL, Tummers B, Green DR
Cell Death Differ 2019 Jan

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Shin D, Kim EH, Lee J, Roh JL
Free Radic Biol Med 2018 Dec

Cell Death Analysis in Retinal Cultures.
Roche SL, Ruiz-Lopez AM, Cotter TG
Methods Mol Biol 2019

Reciprocal regulations between miRNAs and HIF-1α in human cancers.
Yang W, Ma J, Zhou W, Cao B, Zhou X, et al.
Cell Mol Life Sci 2019 Feb

MicroRNA-645 represses hepatocellular carcinoma progression by inhibiting SOX30-mediated p53 transcriptional activation.
Tao J, Liu Z, Wang Y, Wang L, Yin G, et al.
Int J Biol Macromol 2019 Jan

Copper-induced cell death and the protective role of glutathione: the implication of impaired protein folding rather than oxidative stress.
Saporito-Magriñá CM, Musacco-Sebio RN, Andrieux G, Kook L, Orrego MT, et al.
Metallomics 2018 Dec 12

Identification of a novel biomarker in tangeretin‑induced cell death in AGS human gastric cancer cells.
Yumnam S, Raha S, Kim SM, Venkatarame Gowda Saralamma V, Lee HJ, et al.
Oncol Rep 2018 Dec

Altered mRNA expression levels of the major components of sphingolipid metabolism, ceramide synthases and their clinical implication in colorectal cancer.
Jang SW, Park WJ, Min H, Kwon TK, Baek SK, et al.
Oncol Rep 2018 Dec

IP₃ receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice.
Valladares D, Utreras-Mendoza Y, Campos C, Morales C, Diaz-Vegas A, et al.
Biochim Biophys Acta Mol Basis Dis 2018 Nov

Autophagy mediates calcium-sensing receptor-induced TNFα production in human preadipocytes.
Mattar P, Bravo-Sagua R, Tobar N, Fuentes C, Troncoso R, et al.
Biochim Biophys Acta Mol Basis Dis 2018 Nov

Activation of α7 nicotinic acetylcholine receptor alleviates Aβ_1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.
Chang KW, Zong HF, Ma KG, Zhai WY, Yang WN, et al.
Neurochem Int 2018 Nov

<i>Caenorhabditis elegans ced-3</i> Caspase Is Required for Asymmetric Divisions That Generate Cells Programmed To Die.
Mishra N, Wei H, Conradt B
Genetics 2018 Nov

Whi2 signals low leucine availability to halt yeast growth and cell death.
Teng X, Yau E, Sing C, Hardwick JM
FEMS Yeast Res 2018 Dec 1

Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells by regulation of the JAK2/STAT3 signaling pathway.
Oh HN, Seo JH, Lee MH, Kim C, Kim E, et al.
J Cell Biochem 2018 Dec

miR-23c suppresses tumor growth of human hepatocellular carcinoma by attenuating ERBB2IP.
Zhang L, Wang Y, Wang L, Yin G, Li W, et al.
Biomed Pharmacother 2018 Nov

Pyrethroid bifenthrin induces oxidative stress, neuroinflammation, and neuronal damage, associated with cognitive and memory impairment in murine hippocampus.
Gargouri B, Yousif NM, Attaai A, Bouchard M, Chtourou Y, et al.
Neurochem Int 2018 Nov

Long non-coding RNA TUG1 sponges miR-197 to enhance cisplatin sensitivity in triple negative breast cancer.
Tang T, Cheng Y, She Q, Jiang Y, Chen Y, et al.
Biomed Pharmacother 2018 Nov

Adrenomedullin Reduces Secondary Injury and Improves Outcome in Rats with Fluid Percussion Brain Injury.
Gao W, Ju YN, Chen JF, Zhou Q, Song CY, et al.
World Neurosurg 2018 Nov

Intranuclear delivery of synthetic nuclear factor-kappa B p65 reduces inflammasomes after surgery.
Cheon SY, Kim JM, Kim EJ, Kim SY, Kam EH, et al.
Biochem Pharmacol 2018 Dec

microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis.
Volin M, Zohar-Fux M, Gonen O, Porat-Kuperstein L, Toledano H, et al.
J Cell Biol 2018 Nov 5

Moringa oleifera stem extract protect skin keratinocytes against oxidative stress injury by enhancement of antioxidant defense systems and activation of PPARα.
Zhou Y, Yang W, Li Z, Luo D, Li W, et al.
Biomed Pharmacother 2018 Nov

Renal dysfunction is rare in Fukuyama congenital muscular dystrophy.
Ishigaki K, Kato I, Murakami T, Sato T, Shichiji M, et al.
Brain Dev 2019 Jan

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications.
Almanza A, Carlesso A, Chintha C, Creedican S, Doultsinos D, et al.
FEBS J 2019 Jan

Melatonin improves cardiac and mitochondrial function during doxorubicin-induced cardiotoxicity: A possible role for peroxisome proliferator-activated receptor gamma coactivator 1-alpha and sirtuin activity?
Govender J, Loos B, Marais E, Engelbrecht AM
Toxicol Appl Pharmacol 2018 Nov 1

Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation.
Kim SY, Hong M, Heo SH, Park S, Kwon TK, et al.
Mol Carcinog 2018 Nov

BNIP3 contributes to the glutamine-driven aggressive behavior of melanoma cells.
Vara-Perez M, Maes H, Van Dingenen S, Agostinis P
Biol Chem 2019 Jan 28

Reduction of myocardial ischaemia-reperfusion injury by inactivating oxidized phospholipids.
Yeang C, Hasanally D, Que X, Hung MY, Stamenkovic A, et al.
Cardiovasc Res 2019 Jan 1

Redox Dichotomy in Cell Fate Decision: Evasive Mechanism or Achilles Heel?
Pervaiz S
Antioxid Redox Signal 2018 Nov 1

Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.
Fang L, Du WW, Lyu J, Dong J, Zhang C, et al.
Cell Death Differ 2018 Dec

Changes in interleukin-10 and apoptotic genes in rats with myocardial infarction.
Yang W, Zhao Y, Liu N, Cao X, Xing C, et al.
Minerva Med 2019 Feb

Boron Affects the Development of the Kidney Through Modulation of Apoptosis, Antioxidant Capacity, and Nrf2 Pathway in the African Ostrich Chicks.
Khaliq H, Jing W, Ke X, Ke-Li Y, Peng-Peng S, et al.
Biol Trace Elem Res 2018 Nov

BIX-01294 sensitizes renal cancer Caki cells to TRAIL-induced apoptosis through downregulation of survivin expression and upregulation of DR5 expression.
Woo SM, Seo SU, Min KJ, Kwon TK
Cell Death Discov 2018 Dec

MicroRNA-623 Targets Cyclin D1 to Inhibit Cell Proliferation and Enhance the Chemosensitivity of Cells to 5-Fluorouracil in Gastric Cancer.
Jiang L, Yang W, Bian W, Yang H, Wu X, et al.
Oncol Res 2018 Dec 27

Cross Talk Between Cellular Redox State and the Antiapoptotic Protein Bcl-2.
Pohl SÖ, Agostino M, Dharmarajan A, Pervaiz S
Antioxid Redox Signal 2018 Nov 1

Reactive Oxygen Species and Oncoprotein Signaling-A Dangerous Liaison.
Chong SJF, Lai JXH, Eu JQ, Bellot GL, Pervaiz S, et al.
Antioxid Redox Signal 2018 Dec 1