Member Publications

Selective toxicity of tumor treating fields to melanoma: an in vitro and in vivo study.
Jo Y, Hwang SG, Jin YB, Sung J, Jeong YK, et al.
Cell Death Discov 2018

Identification of a novel biomarker in tangeretin‑induced cell death in AGS human gastric cancer cells.
Yumnam S, Raha S, Kim SM, Venkatarame Gowda Saralamma V, Lee HJ, et al.
Oncol Rep 2018 Sep 24

<i>Drosophila</i> HUWE1 Ubiquitin Ligase Regulates Endoreplication and Antagonizes JNK Signaling During Salivary Gland Development.
Yanku Y, Bitman-Lotan E, Zohar Y, Kurant E, Zilke N, et al.
Cells 2018 Sep 26

MiR-1260b inhibitor enhances the chemosensitivity of colorectal cancer cells to fluorouracil by targeting PDCD4/IGF1.
Zhao J, Cao J, Zhou L, Du Y, Zhang X, et al.
Oncol Lett 2018 Oct

Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells.
Zielke S, Meyer N, Mari M, Abou-El-Ardat K, Reggiori F, et al.
Cell Death Dis 2018 Sep 24

Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival.
Russo R, Varano GP, Adornetto A, Nazio F, Tettamanti G, et al.
Cell Death Dis 2018 Sep 24

The Unfolded Protein Response in Breast Cancer.
McGrath EP, Logue SE, Mnich K, Deegan S, Jäger R, et al.
Cancers (Basel) 2018 Sep 21

Autophagy-dependent cell death - where, how and why a cell eats itself to death.
Bialik S, Dasari SK, Kimchi A
J Cell Sci 2018 Sep 20

About canonical, non-canonical and immunogenic cell death: Basic mechanisms and translational applications: A meeting report of the International Cell Death Society.
Zakeri Z, Lockshin RA, Diederich M
Biochem Pharmacol 2018 Sep 14

RAB-35 and ARF-6 GTPases Mediate Engulfment and Clearance Following Linker Cell-Type Death.
Kutscher LM, Keil W, Shaham S
Dev Cell 2018 Sep 7

Activation of α7 nicotinic acetylcholine receptor alleviates Aβ_1-42-induced neurotoxicity via downregulation of p38 and JNK MAPK signaling pathways.
Chang KW, Zong HF, Ma KG, Zhai WY, Yang WN, et al.
Neurochem Int 2018 Nov

Influence of silibinin and β-β-dimethylacrylshikonin on chordoma cells.
Zohreh J, Alexander S, Ines A, Florian K, Birgit L, et al.
Phytomedicine 2018 Oct 1

The Possible Role of Neurobeachin in Extinction of Contextual Fear Memory.
Lee B, Bang E, Yang WS, Paydar A, Ha GE, et al.
Sci Rep 2018 Sep 13

Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.
Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, et al.
Cell Death Differ 2018 Sep 12

Soft Coral <i>Dendronephthya puetteri</i> Extract Ameliorates Inflammations by Suppressing Inflammatory Mediators and Oxidative Stress in LPS-Stimulated Zebrafish.
Kim EA, Ding Y, Yang HW, Heo SJ, Lee SH, et al.
Int J Mol Sci 2018 Sep 10

FAF1 mediates necrosis through JNK1-mediated mitochondrial dysfunction leading to retinal degeneration in the ganglion cell layer upon ischemic insult.
Yu C, Kim BS, Park M, Do YJ, Kong YY, et al.
Cell Commun Signal 2018 Sep 10

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model.
Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, et al.
Science 2018 Sep 7

Involvement of Up-Regulation of DR5 Expression and Down-Regulation of c-FLIP in Niclosamide-Mediated TRAIL Sensitization in Human Renal Carcinoma Caki Cells.
Yun JM, Woo SM, Seo SU, Min KJ, Kim DE, et al.
Molecules 2018 Sep 5

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation.
Faletti L, Peintner L, Neumann S, Sandler S, Grabinger T, et al.
Cell Death Dis 2018 Sep 5

TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway.
Yang W, Liu L, Li C, Luo N, Chen R, et al.
Cell Death Dis 2018 Sep 5

Spatiotemporal Protein Atlas of Cell Death-Related Molecules in the Rat MCAO Stroke Model.
Yoon JS, Jo D, Lee HS, Yoo SW, Lee TY, et al.
Exp Neurobiol 2018 Aug

Loss of RIPK3 and Caspase-8 Augments Intrinsic Apoptosis in Tubular Epithelial Cell and promote Kidney Ischemia Reperfusion Injury.
Sung B, Su Y, Jiang J, Mcleod P, Liu W, et al.
Nephrology (Carlton) 2018 Sep 3

Apoptosis Signal-regulating Kinase 1 Silencing on Astroglial Inflammasomes in an Experimental Model of Ischemic Stroke.
Cheon SY, Kim EJ, Kim SY, Kim JM, Kam EH, et al.
Neuroscience 2018 Oct 15

Characterization of MLKL-mediated Plasma Membrane Rupture in Necroptosis.
McNamara DE, Quarato G, Guy CS, Green DR, Moldoveanu T, et al.
J Vis Exp 2018 Aug 7

DNA Mismatch Repair Protein Immunohistochemistry and MLH1 Promotor Methylation Testing for Practical Molecular Classification and the Prediction of Prognosis in Endometrial Cancer.
Kim J, Kong JK, Yang W, Cho H, Chay DB, et al.
Cancers (Basel) 2018 Aug 21

Licochalcone C induced apoptosis in human oral squamous cell carcinoma cells by regulation of the JAK2/STAT3 signaling pathway.
Oh HN, Seo JH, Lee MH, Kim C, Kim E, et al.
J Cell Biochem 2018 Aug 20

Z-FL-COCHO, a cathepsin S inhibitor, enhances oxaliplatin-mediated apoptosis through the induction of endoplasmic reticulum stress.
Seo SU, Min KJ, Woo SM, Kwon TK
Exp Mol Med 2018 Aug 17

Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
Chang TK, Lawrence DA, Lu M, Tan J, Harnoss JM, et al.
Mol Cell 2018 Aug 16

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1.
Cha JH, Yang WH, Xia W, Wei Y, Chan LC, et al.
Mol Cell 2018 Aug 16

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy.
Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, et al.
Nat Commun 2018 Aug 15

Pyrethroid bifenthrin induces oxidative stress, neuroinflammation, and neuronal damage, associated with cognitive and memory impairment in murine hippocampus.
Gargouri B, Yousif NM, Attaai A, Bouchard M, Chtourou Y, et al.
Neurochem Int 2018 Nov

Long non-coding RNA TUG1 sponges miR-197 to enhance cisplatin sensitivity in triple negative breast cancer.
Tang T, Cheng Y, She Q, Jiang Y, Chen Y, et al.
Biomed Pharmacother 2018 Nov

Pectolinarigenin Induced Cell Cycle Arrest, Autophagy, and Apoptosis in Gastric Cancer Cell via PI3K/AKT/mTOR Signaling Pathway.
Lee HJ, Venkatarame Gowda Saralamma V, Kim SM, Ha SE, Raha S, et al.
Nutrients 2018 Aug 8

Intranuclear delivery of synthetic nuclear factor-kappa B p65 reduces inflammasomes after surgery.
Cheon SY, Kim JM, Kim EJ, Kim SY, Kam EH, et al.
Biochem Pharmacol 2018 Aug 7

microRNAs selectively protect hub cells of the germline stem cell niche from apoptosis.
Volin M, Zohar-Fux M, Gonen O, Porat-Kuperstein L, Toledano H, et al.
J Cell Biol 2018 Aug 9

Renal dysfunction is rare in Fukuyama congenital muscular dystrophy.
Ishigaki K, Kato I, Murakami T, Sato T, Shichiji M, et al.
Brain Dev 2018 Aug 1

Droxinostat sensitizes human colon cancer cells to apoptotic cell death via induction of oxidative stress.
Huang Y, Yang W, Zeng H, Hu C, Zhang Y, et al.
Cell Mol Biol Lett 2018

Do Fungi Undergo Apoptosis-Like Programmed Cell Death?
Hardwick JM
MBio 2018 Jul 31

Protection of the myocardium against ischemia/reperfusion injury by angiotensin-(1-9) through an AT₂R and Akt-dependent mechanism.
Mendoza-Torres E, Riquelme JA, Vielma A, Sagredo AR, Gabrielli L, et al.
Pharmacol Res 2018 Sep

Effect of Productive Human Papillomavirus 16 Infection on Global Gene Expression in Cervical Epithelium.
Kang SD, Chatterjee S, Alam S, Salzberg AC, Milici J, et al.
J Virol 2018 Oct 15

Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications.
Almanza A, Carlesso A, Chintha C, Creedican S, Doultsinos D, et al.
FEBS J 2018 Jul 20

Caspases maintain tissue integrity by an apoptosis-independent inhibition of cell migration and invasion.
Gorelick-Ashkenazi A, Weiss R, Sapozhnikov L, Florentin A, Tarayrah-Ibraheim L, et al.
Nat Commun 2018 Jul 18

Programmed Cell Death in Immune Defense: Knowledge and Presumptions.
Wallach D, Kang TB
Immunity 2018 Jul 17

Garcinol Enhances TRAIL-Induced Apoptotic Cell Death through Up-Regulation of DR5 and Down-Regulation of c-FLIP Expression.
Kim S, Seo SU, Min KJ, Woo SM, Nam JO, et al.
Molecules 2018 Jul 2

Angelica gigas Nakai and Decursin Downregulate Myc Expression to Promote Cell Death in B-cell Lymphoma.
Kim E, Nam J, Chang W, Zulfugarov IS, Okhlopkova ZM, et al.
Sci Rep 2018 Jul 12

Confirming a critical role for death receptor 5 and caspase-8 in apoptosis induction by endoplasmic reticulum stress.
Lam M, Lawrence DA, Ashkenazi A, Walter P
Cell Death Differ 2018 Jul 10

Dihydromyricetin Inhibits Lead-Induced Cognitive Impairments and Inflammation by the Adenosine 5'-Monophosphate-Activated Protein Kinase Pathway in Mice.
Liu CM, Yang W, Ma JQ, Yang HX, Feng ZJ, et al.
J Agric Food Chem 2018 Aug 1

SOX17 restrains proliferation and tumor formation by down-regulating activity of the Wnt/β-catenin signaling pathway via trans-suppressing β-catenin in cervical cancer.
Li L, Yang WT, Zheng PS, Liu XF
Cell Death Dis 2018 Jul 3

Inhibition of euchromatin histone-lysine N-methyltransferase 2 sensitizes breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through reactive oxygen species-mediated activating transcription factor 4-C/EBP homologous protein-death receptor 5 pathway activation.
Kim SY, Hong M, Heo SH, Park S, Kwon TK, et al.
Mol Carcinog 2018 Nov

OTULIN limits cell death and inflammation by deubiquitinating LUBAC.
Heger K, Wickliffe KE, Ndoja A, Zhang J, Murthy A, et al.
Nature 2018 Jul

AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells.
Meyer N, Zielke S, Michaelis JB, Linder B, Warnsmann V, et al.
Autophagy 2018

CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer.
Kim EH, Shin D, Lee J, Jung AR, Roh JL, et al.
Cancer Lett 2018 Sep 28

BNIP3 contributes to the glutamine-driven aggressive behavior of melanoma cells.
Vara-Perez M, Maes H, Van Dingenen S, Agostinis P
Biol Chem 2018 Jul 20

The role of Twist1 in mutant huntingtin-induced transcriptional alterations and neurotoxicity.
Pan Y, Zhu Y, Yang W, Tycksen E, Liu S, et al.
J Biol Chem 2018 Jul 27

BCL-2 selective inhibitor ABT-199 primes rhabdomyosarcoma cells to histone deacetylase inhibitor-induced apoptosis.
Heinicke U, Haydn T, Kehr S, Vogler M, Fulda S, et al.
Oncogene 2018 Sep

mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy.
Seo SU, Woo SM, Lee HS, Kim SH, Min KJ, et al.
Oncogene 2018 Sep

Redox Dichotomy in Cell Fate Decision: Evasive Mechanism or Achilles Heel?
Pervaiz S
Antioxid Redox Signal 2018 Nov 1

Globular adiponectin protects rat hepatocytes against acetaminophen-induced cell death via modulation of the inflammasome activation and ER stress: Critical role of autophagy induction.
Kim EH, Park PH
Biochem Pharmacol 2018 Aug

Anti-tumor properties of anthocyanins from Lonicera caerulea 'Beilei' fruit on human hepatocellular carcinoma: In vitro and in vivo study.
Zhou L, Wang H, Yi J, Yang B, Li M, et al.
Biomed Pharmacother 2018 Aug

Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression.
Yang WH, Cha JH, Xia W, Lee HH, Chan LC, et al.
Cancer Res 2018 Jul 15

Antibody fragment-conjugated gemcitabine and paclitaxel-based liposome for effective therapeutic efficacy in pancreatic cancer.
Yang W, Hu Q, Xu Y, Liu H, Zhong L, et al.
Mater Sci Eng C Mater Biol Appl 2018 Aug 1

Author Correction: Hypericin-based photodynamic therapy induces surface exposure of damage-associated molecular patterns like HSP70 and calreticulin.
Garg AD, Krysko DV, Vandenabeele P, Agostinis P
Cancer Immunol Immunother 2018 Jul

Co-targeting of BET proteins and HDACs as a novel approach to trigger apoptosis in rhabdomyosarcoma cells.
Enßle JC, Boedicker C, Wanior M, Vogler M, Knapp S, et al.
Cancer Lett 2018 Aug 1

Hedgehog signaling negatively co-regulates BH3-only protein Noxa and TAp73 in TP53-mutated cells.
Meister MT, Boedicker C, Klingebiel T, Fulda S
Cancer Lett 2018 Aug 10

PRMT1 negatively regulates activation-induced cell death in macrophages by arginine methylation of GAPDH.
Cho JH, Lee R, Kim E, Choi YE, Choi EJ, et al.
Exp Cell Res 2018 Jul 1

Eupatilin inhibits adipogenesis through suppression of PPARγ activity in 3T3-L1 cells.
Kim JS, Lee SG, Min K, Kwon TK, Kim HJ, et al.
Biomed Pharmacother 2018 Jul

Clinical implication of programmed cell death-1 ligand-1 expression in tonsillar squamous cell carcinoma in association with intratumoral heterogeneity, human papillomavirus, and epithelial-to-mesenchymal transition.
Kwon MJ, Rho YS, Nam ES, Cho SJ, Park HR, et al.
Hum Pathol 2018 Oct

Taurine prevents ethanol-induced apoptosis mediated by mitochondrial or death receptor pathways in liver cells.
Wu G, Yang J, Lv H, Jing W, Zhou J, et al.
Amino Acids 2018 Jul

Structural characterization of a polysaccharide from the flower buds of Tussilago farfara, and its effect on proliferation and apoptosis of A549 human non-small lung cancer cell line.
Qu H, Yang W, Li J
Int J Biol Macromol 2018 Jul 1

Effects of microRNA-133b on retinal vascular endothelial cell proliferation and apoptosis through angiotensinogen-mediated angiotensin II- extracellular signal-regulated kinase 1/2 signalling pathway in rats with diabetic retinopathy.
Liu TT, Hao Q, Zhang Y, Li ZH, Cui ZH, et al.
Acta Ophthalmol 2018 Aug

Circulating Plasma Cells at the Time of Collection of Autologous PBSC for Transplant in Multiple Myeloma Patients is a Negative Prognostic Factor Even in the Age of Post-Transplant Maintenance Therapy.
Cowan AJ, Stevenson PA, Libby EN, Becker PS, Coffey DG, et al.
Biol Blood Marrow Transplant 2018 Jul

Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy.
Choi SR, Lim JH, Kim MY, Kim EN, Kim Y, et al.
Metabolism 2018 Aug

Noninvasive Whole-Body Imaging of Phosphatidylethanolamine as a Cell Death Marker Using ^99mTc-Duramycin During TNF-Induced SIRS.
Delvaeye T, Wyffels L, Deleye S, Lemeire K, Gonçalves A, et al.
J Nucl Med 2018 Jul

Mouse lung fibroblasts are highly susceptible to necroptosis in a reactive oxygen species-dependent manner.
Hussain M, Zimmermann V, van Wijk SJL, Fulda S
Biochem Pharmacol 2018 Jul

Therapeutic opportunities based on caspase modulation.
Fulda S
Semin Cell Dev Biol 2018 Oct

microRNA-137 promotes endothelial progenitor cell proliferation and angiogenesis in cerebral ischemic stroke mice by targeting NR4A2 through the Notch pathway.
Liu XL, Wang G, Song W, Yang WX, Hua J, et al.
J Cell Physiol 2018 Jul

Tomatidine inhibits tumor necrosis factor-α-induced apoptosis in C₂C₁₂ myoblasts via ameliorating endoplasmic reticulum stress.
Song SE, Shin SK, Cho HW, Im SS, Bae JH, et al.
Mol Cell Biochem 2018 Jul

RASGRP1 mutation in autoimmune lymphoproliferative syndrome-like disease.
Mao H, Yang W, Latour S, Yang J, Winter S, et al.
J Allergy Clin Immunol 2018 Aug

An unexpected friend - ROS in apoptosis-induced compensatory proliferation: Implications for regeneration and cancer.
Diwanji N, Bergmann A
Semin Cell Dev Biol 2018 Aug

ROS signalling in the biology of cancer.
Moloney JN, Cotter TG
Semin Cell Dev Biol 2018 Aug