Member Publications

YAP/TFEB pathway promotes autophagic cell death and hypertrophic cardiomyopathy in lysosomal storage diseases.
Rabinovich-Nikitin I, Kirshenbaum LA
J Clin Invest 2021 Mar 1

Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process.
Taghizadeh M, Maghsoudi N, Manaheji H, Akparov V, Baniasadi M, et al.
Heliyon 2021 Feb

Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment.
Mishchenko TA, Balalaeva IV, Vedunova MV, Krysko DV
Trends Cancer 2021 Feb 24

Collagen Type X Alpha 1 (COL10A1) Contributes to Cell Proliferation, Migration, and Invasion by Targeting Prolyl 4-Hydroxylase Beta Polypeptide (P4HB) in Breast Cancer.
Yang W, Wu X, Zhou F
Med Sci Monit 2021 Feb 27

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, et al.
Autophagy 2021 Feb 8

p53 induces ARTS to promote mitochondrial apoptosis.
Hao Q, Chen J, Liao J, Huang Y, Gan Y, et al.
Cell Death Dis 2021 Feb 24

Zinc transporter ZIP7 is a novel determinant of ferroptosis.
Chen PH, Wu J, Xu Y, Ding CC, Mestre AA, et al.
Cell Death Dis 2021 Feb 19

Pretest Symptom Duration and Cycle Threshold Values for Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-Transcription Polymerase Chain Reaction Predict Coronavirus Disease 2019 Mortality.
Miller EH, Zucker J, Castor D, Annavajhala MK, Sepulveda JL, et al.
Open Forum Infect Dis 2021 Feb

Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis.
Liu M, Wang D, Luo Y, Hu L, Bi Y, et al.
Cell Death Dis 2021 Feb 16

Intracellular Ca^{2 +} Imbalance Critically Contributes to Paraptosis.
Kim E, Lee DM, Seo MJ, Lee HJ, Choi KS, et al.
Front Cell Dev Biol 2020

Systemic Immunomodulatory Effects of Combinatorial Treatment of Thalidomide and Dexamethasone on T Cells and Other Immune Cells.
Kim EJ, Kim JY, Choi HY, Lee H, Lee J, et al.
Yonsei Med J 2021 Feb

Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection.
Zhang J, Chen C, Li A, Jing W, Sun P, et al.
Nat Nanotechnol 2021 Feb 1

Tomato SlPUB24 enhances resistance to Xanthomonas euvesicatoria pv. perforans race T3.
Liu X, Meng G, Wang M, Qian Z, Zhang Y, et al.
Hortic Res 2021 Feb 1

Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia/reperfusion injury.
Stamenkovic A, O'Hara KA, Nelson DC, Maddaford TG, Edel AL, et al.
Am J Physiol Heart Circ Physiol 2021 Jan 29

Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma.
Yuan Q, Yang W, Zhang S, Li T, Zuo M, et al.
Mol Med 2021 Jan 28

Impact of different patterns of metastasis in non-small-cell lung cancer patients.
da Silva LM, da Silva GT, Bergmann A, Costa GJ, Zamboni MM, et al.
Future Oncol 2021 Mar

Deubiquitylating enzymes in neuronal health and disease.
Amer-Sarsour F, Kordonsky A, Berdichevsky Y, Prag G, Ashkenazi A, et al.
Cell Death Dis 2021 Jan 22

HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway.
Lei D, Yang WT, Zheng PS
Cell Death Dis 2021 Jan 21

Cell-cycle risk score more accurately determines the risk for metastases and death in prostatectomy patients compared with clinical features alone.
Swanson GP, Lenz L, Stone S, Cohen T
Prostate 2021 Mar

NINJ1 mediates plasma membrane rupture during lytic cell death.
Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, et al.
Nature 2021 Jan 20

Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes.
Xu T, Song Q, Zhou L, Yang W, Wu X, et al.
Nutr Metab (Lond) 2021 Jan 19

Potential Antioxidant Properties of Enzymatic Hydrolysates from Stichopus japonicus against Hydrogen Peroxide-Induced Oxidative Stress.
Lee HG, Kim HS, Oh JY, Lee DS, Yang HW, et al.
Antioxidants (Basel) 2021 Jan 14

Inhibition of ULK1 promotes the death of leukemia cell in an autophagy irrelevant manner and exerts the antileukemia effect.
Yang W, Li Y, Liu S, Sun W, Huang H, et al.
Clin Transl Med 2021 Jan

Modes of Regulated Cell Death in Cancer.
Koren E, Fuchs Y
Cancer Discov 2021 Feb

Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, et al.
Autophagy 2021 Jan 19

MicroRNA-488-3p Regulates Neuronal Cell Death in Cerebral Ischemic Stroke Through Vacuolar Protein Sorting 4B (VPS4B).
Zhou L, Yang W, Yao E, Li H, Wang J, et al.
Neuropsychiatr Dis Treat 2021

Complete response to immunotherapy combined with an antiangiogenic agent in multiple hepatic metastases after radical surgery for advanced gallbladder cancer: a case report.
Rao J, Xia J, Yang W, Wu C, Sha B, et al.
Ann Transl Med 2020 Dec

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future.
Alzeibak R, Mishchenko TA, Shilyagina NY, Balalaeva IV, Vedunova MV, et al.
J Immunother Cancer 2021 Jan

Combinatorial Therapeutic Effect of Inhibitors of Aldehyde Dehydrogenase and Mitochondrial Complex I, and the Chemotherapeutic Drug, Temozolomide against Glioblastoma Tumorspheres.
Park HH, Park J, Cho HJ, Shim JK, Moon JH, et al.
Molecules 2021 Jan 8

Activation mechanisms of inflammasomes by bacterial toxins.
Jing W, Lo Pilato J, Kay C, Man SM
Cell Microbiol 2021 Jan 11

20(S)-Ginsenoside Rh2 Suppresses Oral Cancer Cell Growth by Inhibiting the Src-Raf-ERK Signaling Pathway.
Zhang H, Yi J, Kim E, Choo Y, Hai H, et al.
Anticancer Res 2021 Jan

Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis.
Read DE, Gupta A, Cawley K, Fontana L, Agostinis P, et al.
Life (Basel) 2021 Jan 6

Molecular mechanisms underlying the enhancement of carbon ion beam radiosensitivity of osteosarcoma cells by miR-29b.
Kim EH, Kim JY, Kim MS, Vares G, Ohno T, et al.
Am J Cancer Res 2020

CXCR4 uses STAT3-mediated slug expression to maintain radioresistance of non-small cell lung cancer cells: emerges as a potential prognostic biomarker for lung cancer.
Kim JY, Kim HJ, Jung CW, Lee TS, Kim EH, et al.
Cell Death Dis 2021 Jan 7

Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway.
Xie H, Ma K, Zhang K, Zhou J, Li L, et al.
Cell Death Dis 2021 Jan 5

Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
Prokopi A, Tripp CH, Tummers B, Hornsteiner F, Spoeck S, et al.
J Immunother Cancer 2021 Jan

Acute chest syndrome in pediatric sickle cell disease: Associations with racial composition and neighborhood deprivation.
Alishlash AS, Rutland SB, Friedman AJ, Hampton JI, Nourani A, et al.
Pediatr Blood Cancer 2021 Apr

NRF2 -617 C/A Polymorphism Impacts Proinflammatory Cytokine Levels, Survival, and Transplant-Related Mortality After Hematopoietic Stem Cell Transplantation in Adult Patients Receiving Busulfan-Based Conditioning Regimens.
Huang J, Hao C, Li Z, Wang L, Jiang J, et al.
Front Pharmacol 2020

Protective effects of PARP1-inhibitory compound in dry age-related macular degeneration.
Ho J, Jang KH, Koo TS, Park C, Kim YH, et al.
Biomed Pharmacother 2021 Jan

USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination.
Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, et al.
EMBO Rep 2021 Feb 3

PD-1-Expressing SARS-CoV-2-Specific CD8⁺ T Cells Are Not Exhausted, but Functional in Patients with COVID-19.
Rha MS, Jeong HW, Ko JH, Choi SJ, Seo IH, et al.
Immunity 2021 Jan 12

ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines.
Ehrenfeld V, Heusel JR, Fulda S, van Wijk SJL
PLoS One 2020

4-1BB co-stimulation further enhances anti-PD-1-mediated reinvigoration of exhausted CD39⁺ CD8 T cells from primary and metastatic sites of epithelial ovarian cancers.
Leem G, Park J, Jeon M, Kim ES, Kim SW, et al.
J Immunother Cancer 2020 Dec

Xenopus gpx3 Mediates Posterior Development by Regulating Cell Death during Embryogenesis.
Lee H, Ismail T, Kim Y, Chae S, Ryu HY, et al.
Antioxidants (Basel) 2020 Dec 12

Organelle-specific mechanisms of drug-induced autophagy-dependent cell death.
Zein L, Fulda S, Kögel D, van Wijk SJL
Matrix Biol 2020 Dec 13

Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression.
Woo SM, Min KJ, Kwon TK
Molecules 2020 Dec 8

Dynamic changes in circulating PD-1⁺CD8⁺ T lymphocytes for predicting treatment response to PD-1 blockade in patients with non-small-cell lung cancer.
Kim CG, Hong MH, Kim KH, Seo IH, Ahn BC, et al.
Eur J Cancer 2021 Jan

AFM Analysis Enables Differentiation between Apoptosis, Necroptosis, and Ferroptosis in Murine Cancer Cells.
Van der Meeren L, Verduijn J, Krysko DV, Skirtach AG
iScience 2020 Dec 18

Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor.
Korovesis D, Rufo N, Derua R, Agostinis P, Verhelst SHL, et al.
ACS Chem Biol 2020 Dec 18

Alternate PCR assays for screening of JH1 mutation associated with embryonic death in Jersey cattle.
Kumar A, Gupta ID, Mohan G, M R V, D RK, et al.
Mol Cell Probes 2021 Feb

Inhibition of EZH2 ameliorates bacteria-induced liver injury by repressing RUNX1 in dendritic cells.
Wang Y, Wang Q, Wang B, Gu Y, Yu H, et al.
Cell Death Dis 2020 Dec 1

Methylmercury cytotoxicity and possible mechanisms in human trophoblastic HTR-8/SVneo cells.
Liao Y, Peng S, He L, Wang Y, Li Y, et al.
Ecotoxicol Environ Saf 2021 Jan 1

Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.
Chong SJF, Iskandar K, Lai JXH, Qu J, Raman D, et al.
Nucleic Acids Res 2020 Dec 16

ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Vrijsen S, Besora-Casals L, van Veen S, Zielich J, Van den Haute C, et al.
Proc Natl Acad Sci U S A 2020 Dec 8

Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y, et al.
Life Sci 2021 Jan 15

Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9.
Noori AR, Tashakor A, Nikkhah M, Eriksson LA, Hosseinkhani S, et al.
Biochimie 2021 Jan

Low-Dose Total Skin Electron Beam Therapy as Part of a Multimodality Regimen for Treatment of Sézary Syndrome: Clinical, Immunologic, and Molecular Analysis.
Durgin JS, Jariwala NN, Wysocka M, Zhang KK, Maity A, et al.
JAMA Dermatol 2021 Jan 1

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model.
Yang W, Liu X, Song C, Ji S, Yang J, et al.
Eur J Med Chem 2021 Jan 1

Targeted inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells.
Oh HN, Kwak AW, Lee MH, Kim E, Yoon G, et al.
Phytomedicine 2021 Jan

Pneumocystis jirovecii pneumonia in diffuse large B-cell Lymphoma treated with R-CHOP.
Lee JY, Kang M, Suh KJ, Kim JW, Kim SH, et al.
Mycoses 2021 Jan

Quietness of circular RNA circ_0054633 alleviates the inflammation and proliferation in lipopolysaccharides-induced acute lung injury model through NF-κB signaling pathway.
Yang CL, Yang WK, He ZH, Guo JH, Yang XG, et al.
Gene 2021 Jan 15

LINC01133 and LINC01243 are positively correlated with endometrial carcinoma pathogenesis.
Yang W, Yue Y, Yin F, Qi Z, Guo R, et al.
Arch Gynecol Obstet 2021 Jan

The conserved microRNA miR-210 regulates lipid metabolism and photoreceptor maintenance in the Drosophila retina.
Lyu J, Chen Y, Yang W, Guo T, Xu X, et al.
Cell Death Differ 2021 Feb

Inhibition of NF-κB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.
Lu X, Li Y, Yang W, Tao M, Dai Y, et al.
J Biochem Mol Toxicol 2021 Jan

Epidermal growth factor (EGF)-based activatable probe for predicting therapeutic outcome of an EGF-based doxorubicin prodrug.
Kim HY, Um SH, Sung Y, Shim MK, Yang S, et al.
J Control Release 2020 Dec 10

Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration.
Zhou S, Zhang W, Cai G, Ding Y, Wei C, et al.
Cell Res 2020 Dec

Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.
Wong SW, Huang BW, Hu X, Kim EH, Kolb JP, et al.
Cell Death Differ 2021 Feb

Shikonin induces tumor apoptosis in glioma cells via endoplasmic reticulum stress, and Bax/Bak mediated mitochondrial outer membrane permeability.
Ma X, Yu M, Hao C, Yang W
J Ethnopharmacol 2020 Dec 5

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, et al.
J Hepatol 2020 Dec

Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells.
Hong SW, Shin JS, Moon JH, Jung SA, Koh DI, et al.
Invest New Drugs 2020 Dec

Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling.
Weinelt N, Karathanasis C, Smith S, Medler J, Malkusch S, et al.
J Leukoc Biol 2021 Feb

Enhancing the chemotherapy effect of Apatinib on gastric cancer by co-treating with salidroside to reprogram the tumor hypoxia micro-environment and induce cell apoptosis.
Zhang Z, Yang W, Ma F, Ma Q, Zhang B, et al.
Drug Deliv 2020 Dec

Conditioned media from blue light-emitting diode-exposed fibroblasts have an anti-inflammatory effect in vitro.
Oh PS, Kim EM, Lim S, Sohn MH, Jeong HJ, et al.
Lasers Med Sci 2021 Feb