Member Publications

Extracellular and Intracellular Skeletons: How Do They Involve in Apoptosis.
Ni JH, Yang WX
DNA Cell Biol 2021 Nov 26

COVID-19 pandemic dynamics in India, the SARS-CoV-2 Delta variant, and implications for vaccination.
Yang W, Shaman J
medRxiv 2021 Nov 22

MICU3 regulates mitochondrial Ca²⁺-dependent antioxidant response in skeletal muscle aging.
Yang YF, Yang W, Liao ZY, Wu YX, Fan Z, et al.
Cell Death Dis 2021 Nov 29

Prognostic impact of neutrophilia and lymphopenia on survival in anal cancer treated with definitive concurrent chemoradiotherapy: a retrospective multicenter study.
Kim E, Kim TH, Jung W, Kim K, Chang AR, et al.
Int J Clin Oncol 2021 Nov 29

Temporary Upregulation of Nrf2 by Naringenin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells.
Chen W, Ye Y, Wu Z, Lin J, Wang Y, et al.
Oxid Med Cell Longev 2021

TRAIL sensitivity of nasopharyngeal cancer cells involves redox dependent upregulation of TMTC2 and its interaction with membrane caspase-3.
Raman D, Tay P, Hirpara JL, Liu D, Pervaiz S, et al.
Redox Biol 2021 Nov 20

Outcome of haploidentical peripheral blood allografts utilizing post-transplant cyclophosphamide compared to matched sibling and unrelated donor bone marrow allografts in pediatric patients with hematological malignancies: A single center analysis.
A S, E R, DA W, T S, M A, et al.
Transplant Cell Ther 2021 Nov 24

Melatonin induces apoptotic cell death through Bim stabilization by Sp1-mediated OTUD1 upregulation.
Woo SM, Seo SU, Min KJ, Kwon TK
J Pineal Res 2021 Nov 26

Precise control over the silica shell thickness and finding the optimal thickness for the peak heat diffusion property of AuNR@SiO₂.
Yang W, Kaur S, Kim YD, Kim JM, Lee SH, et al.
J Mater Chem B 2021 Nov 26

Hemodynamic Changes Provoked through Intravascular Injection of the Echis carinatus Venom in Rats.
Zaeri S, Fatemikia H, Kamyab M, Esmaili A, Kim E, et al.
Arch Razi Inst 2021 Summer

Mitochondria-targeted accumulation of oxygen-irrelevant free radicals for enhanced synergistic low-temperature photothermal and thermodynamic therapy.
Hu H, Deng X, Song Q, Yang W, Zhang Y, et al.
J Nanobiotechnology 2021 Nov 25

Exercise Reverses Amyloid Beta-Peptide-mediated Cognitive Deficits in Alzheimer's Disease Mice Expressing Mutant Presenilin-2.
Hwang DJ, Choi DH, Kwon KC, Kim EH, Kim TK, et al.
Med Sci Sports Exerc 2021 Nov 23

Nerve growth factor promotes lysyl oxidase-dependent chondrosarcoma cell metastasis by suppressing miR-149-5p synthesis.
Tzeng HE, Lin SL, Thadevoos LA, Lien MY, Yang WH, et al.
Cell Death Dis 2021 Nov 23

Peripherally-driven myeloid NFkB and IFN/ISG responses predict malignancy risk, survival, and immunotherapy regime in ovarian cancer.
Sprooten J, Vankerckhoven A, Vanmeerbeek I, Borras DM, Berckmans Y, et al.
J Immunother Cancer 2021 Nov

Inhibition of cathepsin K sensitizes oxaliplatin-induced apoptotic cell death by Bax upregulation through OTUB1-mediated p53 stabilization in vitro and in vivo.
Seo SU, Woo SM, Kim S, Park JW, Lee HS, et al.
Oncogene 2021 Nov 16

Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Liao W, Yang W, Xu J, Yan Z, Pan M, et al.
Front Pharmacol 2021

A GLP-1/GLP-2 receptor dual agonist to treat non-alcoholic steatohepatitis: targeting the gut-liver axis and microbiome.
Kim ER, Park JS, Kim JH, Oh JY, Oh IJ, et al.
Hepatology 2021 Nov 12

Apoptotic stress-induced FGF signalling promotes non-cell autonomous resistance to cell death.
Bock FJ, Sedov E, Koren E, Koessinger AL, Cloix C, et al.
Nat Commun 2021 Nov 12

FLLL32 Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells by Regulating the p38 Pathway.
Su CW, Chuang CY, Chen YT, Yang WE, Pan YP, et al.
Int J Mol Sci 2021 Nov 1

Omega-3 Polyunsaturated Fatty Acid Attenuates Uremia-Induced Brain Damage in Mice.
Kim EJ, Ham YR, Shin JA, Jeong JY, Na KR, et al.
Int J Mol Sci 2021 Oct 30

Brainstem and Cortical Spreading Depolarization in a Closed Head Injury Rat Model.
Aboghazleh R, Parker E, Yang LT, Kaufer D, Dreier JP, et al.
Int J Mol Sci 2021 Oct 28

Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1.
Pihán P, Lisbona F, Borgonovo J, Edwards-Jorquera S, Nunes-Hasler P, et al.
Sci Adv 2021 Nov 12

Discovery of putative tumor suppressors from CRISPR screens reveals rewired lipid metabolism in acute myeloid leukemia cells.
Lenoir WF, Morgado M, DeWeirdt PC, McLaughlin M, Griffith AL, et al.
Nat Commun 2021 Nov 11

T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death.
Chun N, Ang RL, Chan M, Fairchild RL, Baldwin Iii WM, et al.
JCI Insight 2021 Nov 9

The integrated stress response in ischemic diseases.
Zhang G, Wang X, Rothermel BA, Lavandero S, Wang ZV, et al.
Cell Death Differ 2021 Nov 6

A gene toolbox for monitoring autophagy transcription.
Bordi M, De Cegli R, Testa B, Nixon RA, Ballabio A, et al.
Cell Death Dis 2021 Nov 2

Immune checkpoint blockade in the treatment of malignant tumor: current statue and future strategies.
Yang W, Lei C, Song S, Jing W, Jin C, et al.
Cancer Cell Int 2021 Nov 2

Revealing the metabolic mechanism of dandelion extract against A549 cells using UPLC-QTOF MS.
Man J, Wu L, Han P, Hao Y, Li J, et al.
Biomed Chromatogr 2021 Nov 2

Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis.
Zhang T, Zhang G, Yang W, Chen H, Hu J, et al.
Cell Death Dis 2021 Oct 25

[6]-Gingerol Suppresses Oral Cancer Cell Growth by Inducing the Activation of AMPK and Suppressing the AKT/mTOR Signaling Pathway.
Zhang H, Kim E, Yi J, Hai H, Kim H, et al.
In Vivo 2021 Nov-Dec

Magnolol Triggers Caspase-Mediated Apoptotic Cell Death in Human Oral Cancer Cells through JNK1/2 and p38 Pathways.
Chen YT, Lin CW, Su CW, Yang WE, Chuang CY, et al.
Biomedicines 2021 Sep 22

Cystine and Methionine Deficiency Promotes Ferroptosis by Inducing B-Cell Translocation Gene 1.
Cho IJ, Kim D, Kim EO, Jegal KH, Kim JK, et al.
Antioxidants (Basel) 2021 Sep 28

Sesamol Ameliorates Renal Injury-Mediated Atherosclerosis via Inhibition of Oxidative Stress/IKKα/p53.
Wang JS, Tsai PH, Tseng KF, Chen FY, Yang WC, et al.
Antioxidants (Basel) 2021 Sep 24

Comparative immunogenicity and effectiveness of mRNA-1273, BNT162b2 and Ad26.COV2.S COVID-19 vaccines.
Naranbhai V, Garcia-Beltran WF, Chang CC, Mairena CB, Thierauf JC, et al.
medRxiv 2021 Oct 13

Balancing life and death: BCL-2 family members at diverse ER-mitochondrial contact sites.
Means RE, Katz SG
FEBS J 2021 Oct 20

Tumor-treating fields as a proton beam-sensitizer for glioblastoma therapy.
Lee WS, Seo SJ, Chung HK, Park JW, Kim JK, et al.
Am J Cancer Res 2021

β-Hydroxybutyrate Exacerbates Hypoxic Injury by Inhibiting HIF-1α-Dependent Glycolysis in Cardiomyocytes-Adding Fuel to the Fire?
Ma X, Dong Z, Liu J, Ma L, Sun X, et al.
Cardiovasc Drugs Ther 2021 Oct 15

Peroxisome proliferator-activated receptor δ rescues xCT-deficient cells from ferroptosis by targeting peroxisomes.
Hwang JS, Kim E, Lee HG, Lee WJ, Won JP, et al.
Biomed Pharmacother 2021 Nov

Cyanoarylporphyrazines with High Viscosity Sensitivity: A Step towards Dosimetry-Assisted Photodynamic Cancer Treatment.
Balalaeva IV, Mishchenko TA, Turubanova VD, Peskova NN, Shilyagina NY, et al.
Molecules 2021 Sep 25

Kansuinine A Ameliorates Atherosclerosis and Human Aortic Endothelial Cell Apoptosis by Inhibiting Reactive Oxygen Species Production and Suppressing IKKβ/IκBα/NF-κB Signaling.
Chen CS, Pan BY, Tsai PH, Chen FY, Yang WC, et al.
Int J Mol Sci 2021 Sep 24

Simvastatin induced ferroptosis for triple-negative breast cancer therapy.
Yao X, Xie R, Cao Y, Tang J, Men Y, et al.
J Nanobiotechnology 2021 Oct 9

Stem cells from exfoliated deciduous teeth transplantation ameliorates Sjögren's syndrome by secreting soluble PD-L1.
Yang N, Liu X, Chen X, Yu S, Yang W, et al.
J Leukoc Biol 2021 Oct 8

Mitochondrial Dynamics in SARS-COV2 Spike Protein Treated Human Microglia: Implications for Neuro-COVID.
Clough E, Chean KT, Inigo J, Tubbesing KE, Chandra D, et al.
J Neuroimmune Pharmacol 2021 Oct 2

Hsa_circ_0011385 knockdown represses cell proliferation in hepatocellular carcinoma.
Ni C, Yang S, Ji Y, Duan Y, Yang W, et al.
Cell Death Discov 2021 Oct 1

Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity.
Chen SH, Dominik PK, Stanfield J, Ding S, Yang W, et al.
J Immunother Cancer 2021 Oct

Knockout of Calcyclin Binding Protein Impedes the Growth of Breast Cancer Cells by Regulating Cell Apoptosis and β-Catenin Signaling.
Wang N, Wang Y, Wang H, Luo N, Yang W, et al.
DNA Cell Biol 2021 Oct

Mitochondrial Quality Control in Hepatocellular Carcinoma.
Bian J, Zhang D, Wang Y, Qin H, Yang W, et al.
Front Oncol 2021

Near-infrared optical spectroscopy for pancreas shrinkage estimation with multi synchrosqueezing transform and multivariate regression model.
S IP, M VP, K S
Microsc Res Tech 2021 Sep 29

Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells.
Yang WB, Wu AC, Hsu TI, Liou JP, Lo WL, et al.
Cell Death Dis 2021 Sep 28

The long non-coding RNA HOTAIRM1 promotes tumor aggressiveness and radiotherapy resistance in glioblastoma.
Ahmadov U, Picard D, Bartl J, Silginer M, Trajkovic-Arsic M, et al.
Cell Death Dis 2021 Sep 28

Inhibition of BMI-1 Induces Apoptosis through Downregulation of DUB3-Mediated Mcl-1 Stabilization.
Wu K, Woo SM, Seo SU, Kwon TK
Int J Mol Sci 2021 Sep 18

Establishment of a Drug Screening Model for Cardiac Complications of Acute Renal Failure.
Liao S, Yang W, Yu T, Dai L, Liu X, et al.
Biomolecules 2021 Sep 16

Rapid Tumor Targeting of Renal-Clearable ZW800-1 Conjugate for Efficient Photothermal Cancer Therapy.
Park MH, Jo G, Lee BY, Kim EJ, Hyun H, et al.
Biomedicines 2021 Sep 3

Development of Nomograms for Predicting Lymph Node Metastasis and Distant Metastasis in Newly Diagnosed T1-2 Non-Small Cell Lung Cancer: A Population-Based Analysis.
Qi Y, Wu S, Tao L, Shi Y, Yang W, et al.
Front Oncol 2021

D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF-2α-dependent manner.
Zhou X, Zheng Y, Sun W, Zhang Z, Liu J, et al.
Cell Prolif 2021 Nov

Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer.
Li H, Yang W, Zhang M, He T, Zhou F, et al.
Epigenomics 2021 Sep

Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.
Kuo TF, Hsu SW, Huang SH, Chang CL, Feng CS, et al.
EMBO Mol Med 2021 Oct 7

BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9 transcription.
Jiang HS, Ghose P, Han HF, Wu YZ, Tsai YY, et al.
Development 2021 Oct 15

Y-2 reduces oxidative stress and inflammation and improves neurological function of collagenase-induced intracerebral hemorrhage rats.
Hua Y, Zhou L, Yang W, An W, Kou X, et al.
Eur J Pharmacol 2021 Nov 5

Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition.
Won M, Choi S, Cheon S, Kim EM, Kwon TK, et al.
Cell Biol Toxicol 2021 Sep 15

Carbamylated erythropoietin improves recognition memory by modulating microglia in a rat model of pain.
Rahmani N, Mohammadi M, Manaheji H, Maghsoudi N, Katinger H, et al.
Behav Brain Res 2022 Jan 7

Docosahexaenoic acid monoglyceride induces apoptosis and autophagy in breast cancer cells via lipid peroxidation-mediated endoplasmic reticulum stress.
Wang TT, Yang Y, Wang F, Yang WG, Zhang JJ, et al.
J Food Sci 2021 Oct

Nanoplasmonic Sandwich Immunoassay for Tumor-Derived Exosome Detection and Exosomal PD-L1 Profiling.
Wang C, Huang CH, Gao Z, Shen J, He J, et al.
ACS Sens 2021 Sep 24

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.
Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, et al.
Cell Host Microbe 2021 Oct 13

Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation.
Xia J, Zhang J, Wang L, Liu H, Wang J, et al.
Cell Death Dis 2021 Sep 4

Deep learning with digital holographic microscopy discriminates apoptosis and necroptosis.
Verduijn J, Van der Meeren L, Krysko DV, Skirtach AG
Cell Death Discov 2021 Sep 2

Phase II Study of Pembrolizumab in Combination with Doxorubicin in Metastatic and Unresectable Soft-Tissue Sarcoma.
Livingston MB, Jagosky MH, Robinson MM, Ahrens WA, Benbow JH, et al.
Clin Cancer Res 2021 Dec 1

Understanding the link between obesity and severe COVID-19 outcomes: Causal mediation by systemic inflammatory response.
Foulkes AS, Selvaggi C, Shinnick D, Lumish H, Kim E, et al.
J Clin Endocrinol Metab 2021 Sep 2

A nanoparticle-containing polycaprolactone implant for combating post-resection breast cancer recurrence.
Gao Y, Wang J, Han H, Xiao H, Jin WK, et al.
Nanoscale 2021 Sep 2

Autophagy in major human diseases.
Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, et al.
EMBO J 2021 Oct 1

The lysosome as a master regulator of iron metabolism.
Rizzollo F, More S, Vangheluwe P, Agostinis P
Trends Biochem Sci 2021 Dec

A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila.
Petrignani B, Rommelaere S, Hakim-Mishnaevski K, Masson F, Ramond E, et al.
EMBO Rep 2021 Sep 6

IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death.
Wang P, Yang W, Guo H, Dong HP, Guo YY, et al.
Adv Sci (Weinh) 2021 Oct

Near-infrared light triggered activation of pro-drug combination cancer therapy and induction of immunogenic cell death.
Kang X, Cai Y, Wang Q, Wang C, Chen W, et al.
Int J Pharm 2021 Sep 25

The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner.
Mnich K, Koryga I, Pakos-Zebrucka K, Thomas M, Logue SE, et al.
J Cell Mol Med 2021 Sep

Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats.
Zhu K, Zhu X, Sun S, Yang W, Liu S, et al.
Exp Neurol 2021 Nov

Serum amyloid A1: Innocent bystander or active participant in cell migration in triple-negative breast cancer?
Olivier DW, Pretorius E, Engelbrecht AM
Exp Cell Res 2021 Sep 1

Redox-Mediated Artificial Non-Enzymatic Antioxidant MXene Nanoplatforms for Acute Kidney Injury Alleviation.
Zhao X, Wang LY, Li JM, Peng LM, Tang CY, et al.
Adv Sci (Weinh) 2021 Sep

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death.
A Z, J SW, A M, E L, I W, et al.
Cell Tissue Res 2021 Oct

Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Rabinovich-Nikitin I, Rasouli M, Reitz CJ, Posen I, Margulets V, et al.
Autophagy 2021 Nov

Low PDCD4 Expression Is Associated With Poor Prognosis of Colorectal Carcinoma.
Kim JY, Lee H, Kim EK, Lee WM, Hong YO, et al.
Appl Immunohistochem Mol Morphol 2021 Oct 1

Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury.
Du K, Oh SH, Dutta RK, Sun T, Yang WH, et al.
Liver Int 2021 Sep

MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma.
Liu H, Chi Z, Jin H, Yang W
Bioengineered 2021 Dec

Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, et al.
Autophagy 2021 Nov

ATF4 links ER stress with reticulophagy in glioblastoma cells.
Zielke S, Kardo S, Zein L, Mari M, Covarrubias-Pinto A, et al.
Autophagy 2021 Sep