Member Publications

Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.
Kuo TF, Hsu SW, Huang SH, Chang CL, Feng CS, et al.
EMBO Mol Med 2021 Sep 20

BLMP-1 promotes developmental cell death in C. elegans by timely repression of ced-9/bcl-2 transcription.
Jiang HS, Ghose P, Han HF, Wu YZ, Tsai YY, et al.
Development 2021 Sep 20

Artificial Intelligence Predicts Severity of COVID-19 Based on Correlation of Exaggerated Monocyte Activation, Excessive Organ Damage and Hyperinflammatory Syndrome: A Prospective Clinical Study.
Krysko O, Kondakova E, Vershinina O, Galova E, Blagonravova A, et al.
Front Immunol 2021

Y-2 reduces oxidative stress and inflammation and improves neurological function of collagenase-induced intracerebral hemorrhage rats.
Hua Y, Zhou L, Yang W, An W, Kou X, et al.
Eur J Pharmacol 2021 Sep 15

Octyl syringate is preferentially cytotoxic to cancer cells via lysosomal membrane permeabilization and autophagic flux inhibition.
Won M, Choi S, Cheon S, Kim EM, Kwon TK, et al.
Cell Biol Toxicol 2021 Sep 15

Carbamylated erythropoietin improves recognition memory by modulating microglia in a rat model of pain.
Rahmani N, Mohammadi M, Manaheji H, Maghsoudi N, Katinger H, et al.
Behav Brain Res 2021 Sep 8

Farrerol Induces Cancer Cell Death via ERK Activation in SKOV3 Cells and Attenuates TNF-α-Mediated Lipolysis.
Chae J, Kim JS, Choi ST, Lee SG, Ojulari OV, et al.
Int J Mol Sci 2021 Aug 30

Docosahexaenoic acid monoglyceride induces apoptosis and autophagy in breast cancer cells via lipid peroxidation-mediated endoplasmic reticulum stress.
Wang TT, Yang Y, Wang F, Yang WG, Zhang JJ, et al.
J Food Sci 2021 Sep 7

Nanoplasmonic Sandwich Immunoassay for Tumor-Derived Exosome Detection and Exosomal PD-L1 Profiling.
Wang C, Huang CH, Gao Z, Shen J, He J, et al.
ACS Sens 2021 Sep 24

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection.
Luchetti G, Roncaioli JL, Chavez RA, Schubert AF, Kofoed EM, et al.
Cell Host Microbe 2021 Sep 1

Programmed cell death protein-1 inhibitors in the treatment of digestive system tumors in Chinese population: an observational study of effectiveness and safety.
Yang W, Chang L, Guo Q, Chen J, Yu W, et al.
Ann Palliat Med 2021 Aug

Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation.
Xia J, Zhang J, Wang L, Liu H, Wang J, et al.
Cell Death Dis 2021 Sep 4

Deep learning with digital holographic microscopy discriminates apoptosis and necroptosis.
Verduijn J, Van der Meeren L, Krysko DV, Skirtach AG
Cell Death Discov 2021 Sep 2

Understanding the link between obesity and severe COVID-19 outcomes: Causal mediation by systemic inflammatory response.
Foulkes AS, Selvaggi C, Shinnick D, Lumish H, Kim E, et al.
J Clin Endocrinol Metab 2021 Sep 2

A nanoparticle-containing polycaprolactone implant for combating post-resection breast cancer recurrence.
Gao Y, Wang J, Han H, Xiao H, Jin WK, et al.
Nanoscale 2021 Sep 2

Autophagy in major human diseases.
Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, et al.
EMBO J 2021 Aug 30

Protective Role of 4-Octyl Itaconate in Murine LPS/D-GalN-Induced Acute Liver Failure via Inhibiting Inflammation, Oxidative Stress, and Apoptosis.
Li R, Yang W, Yin Y, Zhang P, Wang Y, et al.
Oxid Med Cell Longev 2021

Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting.
Rufo N, Korovesis D, Van Eygen S, Derua R, Garg AD, et al.
Cell Death Differ 2021 Aug 27

Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis.
Cyge B, Voronina V, Hoque M, Kim EN, Hall J, et al.
Sci Rep 2021 Aug 26

Hearing Impairment in a Mouse Model of Diabetes Is Associated with Mitochondrial Dysfunction, Synaptopathy, and Activation of the Intrinsic Apoptosis Pathway.
Lyu AR, Kim TH, Shin SA, Kim EH, Yu Y, et al.
Int J Mol Sci 2021 Aug 16

Photodynamic Inactivation Using Natural Bioactive Compound Prevents and Disrupts the Biofilm Produced by Staphylococcus saprophyticus.
Yang W, Wang Z, Li Q, Jia Y, Song S, et al.
Molecules 2021 Aug 4

Mutation SVCT2 promotes cell proliferation, invasion and migration in colorectal cancer.
Park SS, Ryu YS, Koh DI, Hong SW, Moon JH, et al.
J Cancer 2021

The lysosome as a master regulator of iron metabolism.
Rizzollo F, More S, Vangheluwe P, Agostinis P
Trends Biochem Sci 2021 Aug 9

A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila.
Petrignani B, Rommelaere S, Hakim-Mishnaevski K, Masson F, Ramond E, et al.
EMBO Rep 2021 Sep 6

IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death.
Wang P, Yang W, Guo H, Dong HP, Guo YY, et al.
Adv Sci (Weinh) 2021 Aug 8

Deficiency of ROS-Activated TRPM2 Channel Protects Neurons from Cerebral Ischemia-Reperfusion Injury through Upregulating Autophagy.
Hu X, Wu L, Liu X, Zhang Y, Xu M, et al.
Oxid Med Cell Longev 2021

Near-infrared light triggered activation of pro-drug combination cancer therapy and induction of immunogenic cell death.
Kang X, Cai Y, Wang Q, Wang C, Chen W, et al.
Int J Pharm 2021 Sep 25

The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner.
Mnich K, Koryga I, Pakos-Zebrucka K, Thomas M, Logue SE, et al.
J Cell Mol Med 2021 Sep

Fluorescent Materials for Monitoring Mitochondrial Biology.
Chu Y, Park J, Kim E, Lee S
Materials (Basel) 2021 Jul 27

Evaluation of the Prognostic Value of Red Cell Distribution Width to Total Serum Calcium Ratio in Patients with Acute Pancreatitis.
Han TY, Cheng T, Liu BF, He YR, Pan P, et al.
Gastroenterol Res Pract 2021

Alternatively spliced ANLN isoforms synergistically contribute to the progression of head and neck squamous cell carcinoma.
Guo E, Mao X, Wang X, Guo L, An C, et al.
Cell Death Dis 2021 Aug 3

Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats.
Zhu K, Zhu X, Sun S, Yang W, Liu S, et al.
Exp Neurol 2021 Nov

Successful management of lung adenocarcinoma with ALK/EGFR co-alterations and PD-L1 over-expression by bevacizumab combined with chemotherapy.
He H, Yang W, Huang Y, Zhang X, Peng Y, et al.
Angiogenesis 2021 Aug 3

miR-526b-3p inhibits lung cancer cisplatin-resistance and metastasis by inhibiting STAT3-promoted PD-L1.
Chen KB, Yang W, Xuan Y, Lin AJ
Cell Death Dis 2021 Jul 28

Selective activation of PFKL suppresses the phagocytic oxidative burst.
Amara N, Cooper MP, Voronkova MA, Webb BA, Lynch EM, et al.
Cell 2021 Aug 19

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy.
Hu H, Yang W, Liang Z, Zhou Z, Song Q, et al.
J Nanobiotechnology 2021 Jul 27

HO-1 nuclear accumulation and interaction with NPM1 protect against stress-induced endothelial senescence independent of its enzymatic activity.
Luo W, Li J, Li Z, Lin T, Zhang L, et al.
Cell Death Dis 2021 Jul 26

Costunolide Induces Apoptosis via the Reactive Oxygen Species and Protein Kinase B Pathway in Oral Cancer Cells.
Huang H, Yi JK, Lim SG, Park S, Zhang H, et al.
Int J Mol Sci 2021 Jul 13

Programmable Unlocking Nano-Matryoshka-CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response.
Yang J, Li Z, Shen M, Wang Y, Wang L, et al.
Adv Sci (Weinh) 2021 Jul

c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability.
Tomaipitinca L, Petrungaro S, D'Acunzo P, Facchiano A, Dubey A, et al.
Cell Death Dis 2021 Jul 8

LY294002 and sorafenib as inhibitors of intracellular survival pathways in the elimination of human glioma cells by programmed cell death.
A Z, J SW, A M, E L, I W, et al.
Cell Tissue Res 2021 Jul 8

Platelet-rich plasma attenuates intervertebral disc degeneration via delivering miR-141-3p-containing exosomes.
Xu J, Xie G, Yang W, Wang W, Zuo Z, et al.
Cell Cycle 2021 Aug

Combination of Decitabine and a Modified Regimen of Cisplatin, Cytarabine and Dexamethasone: A Potential Salvage Regimen for Relapsed or Refractory Diffuse Large B-Cell Lymphoma After Second-Line Treatment Failure.
Hu J, Wang X, Chen F, Ding M, Dong M, et al.
Front Oncol 2021

Author Correction: Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death.
Deng H, Yang W, Zhou Z, Tian R, Lin L, et al.
Nat Commun 2021 Jul 1

Characterization of the Mitochondrial Genome of a Wheat AL-Type Male Sterility Line and the Candidate CMS Gene.
Hao M, Yang W, Lu W, Sun L, Shoaib M, et al.
Int J Mol Sci 2021 Jun 15

Down-regulation of BCL2L13 renders poor prognosis in clear cell and papillary renal cell carcinoma.
Meng F, Zhang L, Zhang M, Ye K, Guo W, et al.
Cancer Cell Int 2021 Jun 30

Endoplasmic reticulum-mitochondria coupling increases during doxycycline-induced mitochondrial stress in HeLa cells.
Lopez-Crisosto C, Díaz-Vegas A, Castro PF, Rothermel BA, Bravo-Sagua R, et al.
Cell Death Dis 2021 Jun 28

Sinomenine Suppresses Development of Hepatocellular Carcinoma Cells via Inhibiting MARCH1 and AMPK/STAT3 Signaling Pathway.
Yang W, Feng Q, Li M, Su J, Wang P, et al.
Front Mol Biosci 2021

Protective effects of crude chalaza hydrolysates against liver fibrogenesis via antioxidation, anti-inflammation/anti-fibrogenesis, and apoptosis promotion of damaged hepatocytes.
Lin YL, Lu CF, Wu YS, Yang KT, Yang WY, et al.
Poult Sci 2021 Aug

Response to stress in biological disorders: Implications of stress granule assembly and function.
Wang L, Yang W, Li B, Yuan S, Wang F, et al.
Cell Prolif 2021 Aug

[Analysis on Death Cases in Children with Acute Lymphoblastic Leukemia Treated with the CCLG-ALL 2008 Protocol].
Wang Y, Chen XJ, Guo Y, Yang WY, Zou Y, et al.
Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun

G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence.
Sun SN, Ni SH, Li Y, Liu X, Deng JP, et al.
Cell Death Dis 2021 Jun 8

Single-cell transcriptomic analyses of cardiac immune cells reveal that Rel-driven CD72-positive macrophages induce cardiomyocyte injury.
Ni SH, Xu JD, Sun SN, Li Y, Zhou Z, et al.
Cardiovasc Res 2021 Jun 8

Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Rabinovich-Nikitin I, Rasouli M, Reitz CJ, Posen I, Margulets V, et al.
Autophagy 2021 Aug 7

NSrp70 is a lymphocyte-essential splicing factor that controls thymocyte development.
Kim CH, Park SM, Lee SJ, Kim YD, Jang SH, et al.
Nucleic Acids Res 2021 Jun 4

SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18.
Su G, Yang W, Wang S, Geng C, Guan X, et al.
Biochem Biophys Res Commun 2021 Jul 5

Inhibiting xCT/SLC7A11 induces ferroptosis of myofibroblastic hepatic stellate cells but exacerbates chronic liver injury.
Du K, Oh SH, Dutta RK, Sun T, Yang WH, et al.
Liver Int 2021 Sep

AKR1C3 decreased CML sensitivity to Imatinib in bone marrow microenvironment via dysregulation of miR-379-5p.
Pan D, Yang W, Zeng Y, Li W, Wang K, et al.
Cell Signal 2021 Aug

Endothelial cell autophagy in homeostasis and cancer.
Verhoeven J, Baelen J, Agrawal M, Agostinis P
FEBS Lett 2021 Jun

Longitudinal changes in skeletal muscle mass in patients with advanced squamous cell lung cancer.
Lee J, Kim EY, Kim E, Kim KG, Kim YJ, et al.
Thorac Cancer 2021 Jun

A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer.
Kim E, Ahn H, Park H
Mamm Genome 2021 Aug

Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease.
Xu L, Zhou J, Che J, Wang H, Yang W, et al.
Am J Physiol Gastrointest Liver Physiol 2021 Jun 1

The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2.
Yang WH, Lin CC, Wu J, Chao PY, Chen K, et al.
Mol Cancer Res 2021 Jun

PI3Kαδ Inhibitor Combined With Radiation Enhances the Antitumor Immune Effect of Anti-PD1 in a Syngeneic Murine Triple-Negative Breast Cancer Model.
Chang WI, Han MG, Kang MH, Park JM, Kim EE, et al.
Int J Radiat Oncol Biol Phys 2021 Jul 1

Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment.
Mishchenko TA, Balalaeva IV, Vedunova MV, Krysko DV
Trends Cancer 2021 Jun

Organelle-specific mechanisms of drug-induced autophagy-dependent cell death.
Zein L, Fulda S, Kögel D, van Wijk SJL
Matrix Biol 2021 Jun

Prohibitin regulates mTOR pathway via interaction with FKBP8.
Zhang J, Yin Y, Wang J, Zhang J, Liu H, et al.
Front Med 2021 Jun

Weight change and microvascular outcomes in patients with new-onset diabetes: a nationwide cohort study.
Koh ES, Han KD, Kim MK, Kim ES, Lee MK, et al.
Korean J Intern Med 2021 Jul

Drp1-mediated mitochondrial fission is involved in oxidized low-density lipoprotein-induced AF cella poptosis.
Wu W, Jing D, Huang X, Yang W, Shao Z, et al.
J Orthop Res 2021 Jul

Isoform-specific functions of c-Jun N-terminal kinase 1 and 2 in lung ischemia-reperfusion injury through the c-Jun/activator protein-1 pathway.
Tan J, Gao W, Yang W, Zeng X, Wang L, et al.
J Thorac Cardiovasc Surg 2021 Aug