Member Publications

FCN3 functions as a tumor suppressor of lung adenocarcinoma through induction of endoplasmic reticulum stress.
Jang H, Jun Y, Kim S, Kim E, Jung Y, et al.
Cell Death Dis 2021 Apr 15

Endothelial cell autophagy in homeostasis and cancer.
Verhoeven J, Baelen J, Agrawal M, Agostinis P
FEBS Lett 2021 Apr 9

Longitudinal changes in skeletal muscle mass in patients with advanced squamous cell lung cancer.
Lee J, Kim EY, Kim E, Kim KG, Kim YJ, et al.
Thorac Cancer 2021 Apr 7

ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells.
Ji Y, Liu Y, Sun C, Yu L, Wang Z, et al.
Cell Death Dis 2021 Apr 6

Case of slowly progressive type 1 diabetes mellitus with drastically reduced insulin secretory capacity after immune checkpoint inhibitor treatment for advanced renal cell carcinoma.
Yamaguchi H, Miyoshi Y, Uehara Y, Fujii K, Nagata S, et al.
Diabetol Int 2021 Apr

Novel porphyrazine-based photodynamic anti-cancer therapy induces immunogenic cell death.
Turubanova VD, Mishchenko TA, Balalaeva IV, Efimova I, Peskova NN, et al.
Sci Rep 2021 Mar 30

A review on the role of gut microbiota in immune checkpoint blockade therapy for cancer.
Kim E, Ahn H, Park H
Mamm Genome 2021 Mar 30

TNF-induced necroptosis initiates early autophagy events via RIPK3-dependent AMPK activation, but inhibits late autophagy.
Wu W, Wang X, Sun Y, Berleth N, Deitersen J, et al.
Autophagy 2021 Mar 28

MicroRNA-32-5p inhibits epithelial-mesenchymal transition and metastasis in lung adenocarcinoma by targeting SMAD family 3.
Zhang JX, Yang W, Wu JZ, Zhou C, Liu S, et al.
J Cancer 2021

The oncogene Mct-1 promotes progression of hepatocellular carcinoma via enhancement of Yap-mediated cell proliferation.
Yang W, Ni Y, Yang S, Ji Y, Yang X, et al.
Cell Death Discov 2021 Mar 22

Deoxypodophyllotoxin inhibits cell growth and induces apoptosis by blocking EGFR and MET in gefitinib-resistant non-small cell lung cancer.
Kim HS, Oh HN, Kwak AW, Kim E, Lee MH, et al.
J Microbiol Biotechnol 2021 Mar 5

hPER3 promotes adipogenesis via hHSP90AA1-mediated inhibition of Notch1 pathway.
Wan X, Zhu L, Zhao L, Peng L, Xiong J, et al.
Cell Death Dis 2021 Mar 19

Dysregulation of miR-23b-5p promotes cell proliferation via targeting FOXM1 in hepatocellular carcinoma.
Yang X, Yang S, Song J, Yang W, Ji Y, et al.
Cell Death Discov 2021 Mar 15

Perspectives on Organelle Interaction, Protein Dysregulation, and Cancer Disease.
Díaz P, Sandoval-Bórquez A, Bravo-Sagua R, Quest AFG, Lavandero S, et al.
Front Cell Dev Biol 2021

The Hippo Pathway Effector YAP Promotes Ferroptosis via the E3 Ligase SKP2.
Yang WH, Lin CC, Wu J, Chao PY, Chen K, et al.
Mol Cancer Res 2021 Mar 11

Picornavirus 3C - a protease ensuring virus replication and subverting host responses.
Yi J, Peng J, Yang W, Zhu G, Ren J, et al.
J Cell Sci 2021 Mar 10

Cellular senescence: Silent operator and therapeutic target in cancer.
Ramu D, Shan TW, Hirpara JL, Pervaiz S
IUBMB Life 2021 Mar

PD-L1⁺ neutrophils contribute to injury-induced infection susceptibility.
Thanabalasuriar A, Chiang AJ, Morehouse C, Camara M, Hawkins S, et al.
Sci Adv 2021 Mar

Aromadendrin Protects Neuronal Cells from Methamphetamine-Induced Neurotoxicity by Regulating Endoplasmic Reticulum Stress and PI3K/Akt/mTOR Signaling Pathway.
Lee HS, Kim EN, Jeong GS
Int J Mol Sci 2021 Feb 25

Apoptotic Cells induce Proliferation of Peritoneal Macrophages.
Knuth AK, Huard A, Naeem Z, Rappl P, Bauer R, et al.
Int J Mol Sci 2021 Feb 24

The CDT of Helicobacter hepaticus induces pro-survival autophagy and nucleoplasmic reticulum formation concentrating the RNA binding proteins UNR/CSDE1 and P62/SQSTM1.
He W, Azzi-Martin L, Velasco V, Lehours P, Dubus P, et al.
PLoS Pathog 2021 Mar

Assessment of Atg7 and LC3II/LC3, as The Markers of Autophagy, in Sperm of Infertile Men with Globozoospermia: A Case-Control Study.
Foroozan-Boroojeni S, Tavalaee M, Zakeri Z, Lockshin RA, Nasr-Esfahani MH, et al.
Cell J 2021 Apr

The onco-immunological implications of Fusobacterium nucleatum in breast cancer.
Van der Merwe M, Van Niekerk G, Botha A, Engelbrecht AM
Immunol Lett 2021 Apr

YAP/TFEB pathway promotes autophagic cell death and hypertrophic cardiomyopathy in lysosomal storage diseases.
Rabinovich-Nikitin I, Kirshenbaum LA
J Clin Invest 2021 Mar 1

Noopept; a nootropic dipeptide, modulates persistent inflammation by effecting spinal microglia dependent Brain Derived Neurotropic Factor (BDNF) and pro-BDNF expression throughout apoptotic process.
Taghizadeh M, Maghsoudi N, Manaheji H, Akparov V, Baniasadi M, et al.
Heliyon 2021 Feb

Ferroptosis and Photodynamic Therapy Synergism: Enhancing Anticancer Treatment.
Mishchenko TA, Balalaeva IV, Vedunova MV, Krysko DV
Trends Cancer 2021 Feb 24

Collagen Type X Alpha 1 (COL10A1) Contributes to Cell Proliferation, Migration, and Invasion by Targeting Prolyl 4-Hydroxylase Beta Polypeptide (P4HB) in Breast Cancer.
Yang W, Wu X, Zhou F
Med Sci Monit 2021 Feb 27

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, et al.
Autophagy 2021 Jan

p53 induces ARTS to promote mitochondrial apoptosis.
Hao Q, Chen J, Liao J, Huang Y, Gan Y, et al.
Cell Death Dis 2021 Feb 24

Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats.
Nie C, Ding X, A R, Zheng M, Li Z, et al.
Life Sci 2021 May 1

Zinc transporter ZIP7 is a novel determinant of ferroptosis.
Chen PH, Wu J, Xu Y, Ding CC, Mestre AA, et al.
Cell Death Dis 2021 Feb 19

Pretest Symptom Duration and Cycle Threshold Values for Severe Acute Respiratory Syndrome Coronavirus 2 Reverse-Transcription Polymerase Chain Reaction Predict Coronavirus Disease 2019 Mortality.
Miller EH, Zucker J, Castor D, Annavajhala MK, Sepulveda JL, et al.
Open Forum Infect Dis 2021 Feb

Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis.
Liu M, Wang D, Luo Y, Hu L, Bi Y, et al.
Cell Death Dis 2021 Feb 16

Intracellular Ca^{2 +} Imbalance Critically Contributes to Paraptosis.
Kim E, Lee DM, Seo MJ, Lee HJ, Choi KS, et al.
Front Cell Dev Biol 2020

Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis.
Ha JS, Choi HR, Kim IS, Kim EA, Cho SW, et al.
Int J Mol Sci 2021 Jan 26

Systemic Immunomodulatory Effects of Combinatorial Treatment of Thalidomide and Dexamethasone on T Cells and Other Immune Cells.
Kim EJ, Kim JY, Choi HY, Lee H, Lee J, et al.
Yonsei Med J 2021 Feb

Immunostimulant hydrogel for the inhibition of malignant glioma relapse post-resection.
Zhang J, Chen C, Li A, Jing W, Sun P, et al.
Nat Nanotechnol 2021 Feb 1

Tomato SlPUB24 enhances resistance to Xanthomonas euvesicatoria pv. perforans race T3.
Liu X, Meng G, Wang M, Qian Z, Zhang Y, et al.
Hortic Res 2021 Feb 1

Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury.
Stamenkovic A, O'Hara KA, Nelson DC, Maddaford TG, Edel AL, et al.
Am J Physiol Heart Circ Physiol 2021 Mar 1

Inhibition of mitochondrial carrier homolog 2 (MTCH2) suppresses tumor invasion and enhances sensitivity to temozolomide in malignant glioma.
Yuan Q, Yang W, Zhang S, Li T, Zuo M, et al.
Mol Med 2021 Jan 28

Impact of different patterns of metastasis in non-small-cell lung cancer patients.
da Silva LM, da Silva GT, Bergmann A, Costa GJ, Zamboni MM, et al.
Future Oncol 2021 Mar

Deubiquitylating enzymes in neuronal health and disease.
Amer-Sarsour F, Kordonsky A, Berdichevsky Y, Prag G, Ashkenazi A, et al.
Cell Death Dis 2021 Jan 22

HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway.
Lei D, Yang WT, Zheng PS
Cell Death Dis 2021 Jan 21

Cell-cycle risk score more accurately determines the risk for metastases and death in prostatectomy patients compared with clinical features alone.
Swanson GP, Lenz L, Stone S, Cohen T
Prostate 2021 Mar

NINJ1 mediates plasma membrane rupture during lytic cell death.
Kayagaki N, Kornfeld OS, Lee BL, Stowe IB, O'Rourke K, et al.
Nature 2021 Mar

Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes.
Xu T, Song Q, Zhou L, Yang W, Wu X, et al.
Nutr Metab (Lond) 2021 Jan 19

Potential Antioxidant Properties of Enzymatic Hydrolysates from Stichopus japonicus against Hydrogen Peroxide-Induced Oxidative Stress.
Lee HG, Kim HS, Oh JY, Lee DS, Yang HW, et al.
Antioxidants (Basel) 2021 Jan 14

Inhibition of ULK1 promotes the death of leukemia cell in an autophagy irrelevant manner and exerts the antileukemia effect.
Yang W, Li Y, Liu S, Sun W, Huang H, et al.
Clin Transl Med 2021 Jan

Modes of Regulated Cell Death in Cancer.
Koren E, Fuchs Y
Cancer Discov 2021 Feb

Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.
Meyer N, Henkel L, Linder B, Zielke S, Tascher G, et al.
Autophagy 2021 Jan 19

MicroRNA-488-3p Regulates Neuronal Cell Death in Cerebral Ischemic Stroke Through Vacuolar Protein Sorting 4B (VPS4B).
Zhou L, Yang W, Yao E, Li H, Wang J, et al.
Neuropsychiatr Dis Treat 2021

Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future.
Alzeibak R, Mishchenko TA, Shilyagina NY, Balalaeva IV, Vedunova MV, et al.
J Immunother Cancer 2021 Jan

Combinatorial Therapeutic Effect of Inhibitors of Aldehyde Dehydrogenase and Mitochondrial Complex I, and the Chemotherapeutic Drug, Temozolomide against Glioblastoma Tumorspheres.
Park HH, Park J, Cho HJ, Shim JK, Moon JH, et al.
Molecules 2021 Jan 8

Activation mechanisms of inflammasomes by bacterial toxins.
Jing W, Lo Pilato J, Kay C, Man SM
Cell Microbiol 2021 Apr

20(S)-Ginsenoside Rh2 Suppresses Oral Cancer Cell Growth by Inhibiting the Src-Raf-ERK Signaling Pathway.
Zhang H, Yi J, Kim E, Choo Y, Hai H, et al.
Anticancer Res 2021 Jan

Downregulation of miR-17-92 Cluster by PERK Fine-Tunes Unfolded Protein Response Mediated Apoptosis.
Read DE, Gupta A, Cawley K, Fontana L, Agostinis P, et al.
Life (Basel) 2021 Jan 6

CXCR4 uses STAT3-mediated slug expression to maintain radioresistance of non-small cell lung cancer cells: emerges as a potential prognostic biomarker for lung cancer.
Kim JY, Kim HJ, Jung CW, Lee TS, Kim EH, et al.
Cell Death Dis 2021 Jan 7

Cell-cycle arrest and senescence in TP53-wild type renal carcinoma by enhancer RNA-P53-bound enhancer regions 2 (p53BER2) in a p53-dependent pathway.
Xie H, Ma K, Zhang K, Zhou J, Li L, et al.
Cell Death Dis 2021 Jan 5

Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy.
Prokopi A, Tripp CH, Tummers B, Hornsteiner F, Spoeck S, et al.
J Immunother Cancer 2021 Jan

Acute chest syndrome in pediatric sickle cell disease: Associations with racial composition and neighborhood deprivation.
Alishlash AS, Rutland SB, Friedman AJ, Hampton JI, Nourani A, et al.
Pediatr Blood Cancer 2021 Apr

Protective effects of PARP1-inhibitory compound in dry age-related macular degeneration.
Ho J, Jang KH, Koo TS, Park C, Kim YH, et al.
Biomed Pharmacother 2021 Jan

USP22 controls necroptosis by regulating receptor-interacting protein kinase 3 ubiquitination.
Roedig J, Kowald L, Juretschke T, Karlowitz R, Ahangarian Abhari B, et al.
EMBO Rep 2021 Feb 3

PD-1-Expressing SARS-CoV-2-Specific CD8⁺ T Cells Are Not Exhausted, but Functional in Patients with COVID-19.
Rha MS, Jeong HW, Ko JH, Choi SJ, Seo IH, et al.
Immunity 2021 Jan 12

Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Mao S, Jin J, Li Z, Yang W
Mol Med Rep 2021 Feb

Dynamic changes in circulating PD-1⁺CD8⁺ T lymphocytes for predicting treatment response to PD-1 blockade in patients with non-small-cell lung cancer.
Kim CG, Hong MH, Kim KH, Seo IH, Ahn BC, et al.
Eur J Cancer 2021 Jan

Alternate PCR assays for screening of JH1 mutation associated with embryonic death in Jersey cattle.
Kumar A, Gupta ID, Mohan G, M R V, D RK, et al.
Mol Cell Probes 2021 Feb

Methylmercury cytotoxicity and possible mechanisms in human trophoblastic HTR-8/SVneo cells.
Liao Y, Peng S, He L, Wang Y, Li Y, et al.
Ecotoxicol Environ Saf 2021 Jan 1

Shikonin differentially regulates glucose metabolism via PKM2 and HIF1α to overcome apoptosis in a refractory HCC cell line.
Yang W, Liu J, Hou L, Chen Q, Liu Y, et al.
Life Sci 2021 Jan 15

Ethacrynic acid, a loop diuretic, suppresses epithelial-mesenchymal transition of A549 lung cancer cells via blocking of NDP-induced WNT signaling.
Yu L, Kim HJ, Park MK, Byun HJ, Kim EJ, et al.
Biochem Pharmacol 2021 Jan

Compound XiongShao Capsule ameliorates streptozotocin-induced diabetic peripheral neuropathy in rats via inhibiting apoptosis, oxidative - nitrosative stress and advanced glycation end products.
Yu MX, Lei B, Song X, Huang YM, Ma XQ, et al.
J Ethnopharmacol 2021 Mar 25

Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9.
Noori AR, Tashakor A, Nikkhah M, Eriksson LA, Hosseinkhani S, et al.
Biochimie 2021 Jan

Low-Dose Total Skin Electron Beam Therapy as Part of a Multimodality Regimen for Treatment of Sézary Syndrome: Clinical, Immunologic, and Molecular Analysis.
Durgin JS, Jariwala NN, Wysocka M, Zhang KK, Maity A, et al.
JAMA Dermatol 2021 Jan 1

Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model.
Yang W, Liu X, Song C, Ji S, Yang J, et al.
Eur J Med Chem 2021 Jan 1

Targeted inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells.
Oh HN, Kwak AW, Lee MH, Kim E, Yoon G, et al.
Phytomedicine 2021 Jan

Antioxidant functions of DHHC3 suppress anti-cancer drug activities.
Sharma C, Yang W, Steen H, Freeman MR, Hemler ME, et al.
Cell Mol Life Sci 2021 Mar

Pneumocystis jirovecii pneumonia in diffuse large B-cell Lymphoma treated with R-CHOP.
Lee JY, Kang M, Suh KJ, Kim JW, Kim SH, et al.
Mycoses 2021 Jan

Quietness of circular RNA circ_0054633 alleviates the inflammation and proliferation in lipopolysaccharides-induced acute lung injury model through NF-κB signaling pathway.
Yang CL, Yang WK, He ZH, Guo JH, Yang XG, et al.
Gene 2021 Jan 15

LINC01133 and LINC01243 are positively correlated with endometrial carcinoma pathogenesis.
Yang W, Yue Y, Yin F, Qi Z, Guo R, et al.
Arch Gynecol Obstet 2021 Jan

The conserved microRNA miR-210 regulates lipid metabolism and photoreceptor maintenance in the Drosophila retina.
Lyu J, Chen Y, Yang W, Guo T, Xu X, et al.
Cell Death Differ 2021 Feb

Inhibition of NF-κB is required for oleanolic acid to downregulate PD-L1 by promoting DNA demethylation in gastric cancer cells.
Lu X, Li Y, Yang W, Tao M, Dai Y, et al.
J Biochem Mol Toxicol 2021 Jan

Non-lethal message from the Holy Land: The first international conference on nonapoptotic roles of apoptotic proteins.
Arama E, Baena-Lopez LA, Fearnhead HO
FEBS J 2021 Apr

Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.
Wong SW, Huang BW, Hu X, Kim EH, Kolb JP, et al.
Cell Death Differ 2021 Feb

Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling.
Weinelt N, Karathanasis C, Smith S, Medler J, Malkusch S, et al.
J Leukoc Biol 2021 Feb

Conditioned media from blue light-emitting diode-exposed fibroblasts have an anti-inflammatory effect in vitro.
Oh PS, Kim EM, Lim S, Sohn MH, Jeong HJ, et al.
Lasers Med Sci 2021 Feb