Member Publications

Small molecule AZD4635 inhibitor of A_2AR signaling rescues immune cell function including CD103⁺ dendritic cells enhancing anti-tumor immunity.
Borodovsky A, Barbon CM, Wang Y, Ye M, Prickett L, et al.
J Immunother Cancer 2020 Jul

Modeling of Frontotemporal Dementia Using iPSC Technology.
Kim M, Kim HJ, Koh W, Li L, Heo H, et al.
Int J Mol Sci 2020 Jul 27

Ferulic acid protects cardiomyocytes from TNF-α/cycloheximide-induced apoptosis by regulating autophagy.
Li C, Chen L, Song M, Fang Z, Zhang L, et al.
Arch Pharm Res 2020 Jul 27

Inhibition of kinesin motor protein KIFC1 by AZ82 induces multipolar mitosis and apoptosis in prostate cancer cell.
Parvin A, Hao SL, Tan FQ, Yang WX
Gene 2020 Jul 24

Identifying germline APOBEC3B deletion and immune phenotype in Korean patients with operable breast cancer.
Kim SH, Ahn S, Suh KJ, Kim YJ, Park SY, et al.
Breast Cancer Res Treat 2020 Jul 26

Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer.
Catanzaro E, Betari N, Arencibia JM, Montanari S, Sissi C, et al.
Eur J Med Chem 2020 Jul 4

Cell death in animal development.
Ghose P, Shaham S
Development 2020 Jul 24

Comparative proteomic analysis uncovers potential biomarkers involved in the anticancer effect of Scutellarein in human gastric cancer cells.
Saralamma VVG, Vetrivel P, Lee HJ, Kim SM, Ha SE, et al.
Oncol Rep 2020 Sep

Gene expression profiling of glioblastoma cell lines depending on TP53 status after tumor-treating fields (TTFields) treatment.
Lee YJ, Seo HW, Baek JH, Lim SH, Hwang SG, et al.
Sci Rep 2020 Jul 23

Mortalin peptides exert antitumor activities and act as adjuvants to antibody-mediated complement-dependent cytotoxicity.
Jubran R, Saar-Ray M, Wawruszak A, Ziporen L, Donin N, et al.
Int J Oncol 2020 Jul 16

Correction: JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction.
Simula L, Corrado M, Accordi B, Di Rita A, Nazio F, et al.
Cell Death Differ 2020 Jul 20

Rationally designed redirection of natural killer cells anchoring a cytotoxic ligand for pancreatic cancer treatment.
Lee YE, Ju A, Choi HW, Kim JC, Kim EE, et al.
J Control Release 2020 Jul 16

Correction: Global deletion of optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease.
Wong SW, Huang BW, Hu X, Kim EH, Kolb JP, et al.
Cell Death Differ 2020 Jul 16

Neurorestorative Effects of a Novel Fas-Associated Factor 1 Inhibitor in the MPTP Model: An [¹⁸F]FE-PE2I Positron Emission Tomography Analysis Study.
Park HS, Song YS, Moon BS, Yoo SE, Lee JM, et al.
Front Pharmacol 2020

Effect of valproic acid on overall survival in patients with high-grade gliomas undergoing temozolomide: A nationwide population-based cohort study in Taiwan.
Kuo YJ, Yang YH, Lee IY, Chen PC, Yang JT, et al.
Medicine (Baltimore) 2020 Jul 10

Targeting the MAPK7/MMP9 axis for metastasis in primary bone cancer.
Green D, Eyre H, Singh A, Taylor JT, Chu J, et al.
Oncogene 2020 Jul 13

Higher sensitivity of female cells to ethanol: methylation of DNA lowers Cyp2e1, generating more ROS.
Penaloza CG, Cruz M, Germain G, Jabeen S, Javdan M, et al.
Cell Commun Signal 2020 Jul 11

Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca²⁺ homeostasis and promotes cardiac dysfunction.
Olgar Y, Tuncay E, Degirmenci S, Billur D, Dhingra R, et al.
J Cell Mol Med 2020 Jul 11

The Histone Lysine-specific Demethylase 1 Inhibitor, SP2509 Exerts Cytotoxic Effects against Renal Cancer Cells through Downregulation of Bcl-2 and Mcl-1.
Wu K, Woo SM, Kwon TK
J Cancer Prev 2020 Jun 30

Is hydroxychloroquine beneficial for COVID-19 patients?
Li X, Wang Y, Agostinis P, Rabson A, Melino G, et al.
Cell Death Dis 2020 Jul 8

N-Adamantyl-4-methylthiazol-2-amine suppresses glutamate-induced autophagic cell death via PI3K/Akt/mTOR signaling pathways in cortical neurons.
Yang SJ, Han AR, Choi HR, Hwang K, Kim EA, et al.
BMB Rep 2020 Jul 8

Curcumin-1,2,3-Triazole Conjugation for Targeting the Cancer Apoptosis Machinery.
Seghetti F, Di Martino RMC, Catanzaro E, Bisi A, Gobbi S, et al.
Molecules 2020 Jul 5

Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance.
Shahar N, Larisch S
Drug Resist Updat 2020 Jun 20

Reduced mitochondrial resilience enables non-canonical induction of apoptosis after TNF receptor signaling in virus-infected hepatocytes.
Lampl S, Janas MK, Donakonda S, Brugger M, Lohr K, et al.
J Hepatol 2020 Jun 26

A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2.
Mamriev D, Abbas R, Klingler FM, Kagan J, Kfir N, et al.
Cell Death Dis 2020 Jun 25

Triarylpyridine Compounds and Chloroquine Act in Concert to Trigger Lysosomal Membrane Permeabilization and Cell Death in Cancer Cells.
Beauvarlet J, Nath Das R, Alvarez-Valadez K, Martins I, Muller A, et al.
Cancers (Basel) 2020 Jun 18

The pro-apoptotic ARTS protein induces neutrophil apoptosis, efferocytosis, and macrophage reprogramming to promote resolution of inflammation.
Maimon N, Zamir ZZ, Kalkar P, Zeytuni-Timor O, Schif-Zuck S, et al.
Apoptosis 2020 Aug

Risk of bacteremia in patients with cutaneous T-cell lymphoma (CTCL).
Allen PB, Switchenko J, Ayers A, Kim E, Lechowicz MJ, et al.
Leuk Lymphoma 2020 Jun 19

Open-Label, Phase 1 Study of Nivolumab Combined With <i>nab</i>-Paclitaxel Plus Gemcitabine in Advanced Pancreatic Cancer.
Wainberg ZA, Hochster HS, Kim EJ, George B, Kaylan A, et al.
Clin Cancer Res 2020 Jun 18

Methamphetamine induces GSDME-dependent cell death in hippocampal neuronal cells through the endoplasmic reticulum stress pathway.
Liu Y, Wen D, Gao J, Xie B, Yu H, et al.
Brain Res Bull 2020 Sep

Quercetin and chloroquine synergistically kill glioma cells by inducing organelle stress and disrupting Ca²⁺ homeostasis.
Jang E, Kim IY, Kim H, Lee DM, Seo DY, et al.
Biochem Pharmacol 2020 Aug

Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression.
Li S, Weng J, Song F, Li L, Xiao C, et al.
Cell Death Dis 2020 Jun 12

Prognostic factors associated with overall survival in patients with oral cavity squamous cell carcinoma.
Oliveira LL, Bergmann A, Melo AC, Thuler LC
Med Oral Patol Oral Cir Bucal 2020 Jul 1

Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway.
Kim EH, Woodruff MC, Grigoryan L, Maier B, Lee SH, et al.
Elife 2020 Jun 9

Aberrant hyperactivation of cytotoxic T-cell as a potential determinant of COVID-19 severity.
Kang CK, Han GC, Kim M, Kim G, Shin HM, et al.
Int J Infect Dis 2020 Aug

Rituximab for High-Risk, Mature B-Cell Non-Hodgkin's Lymphoma in Children.
Minard-Colin V, Aupérin A, Pillon M, Burke GAA, Barkauskas DA, et al.
N Engl J Med 2020 Jun 4

Correction: FTSJ1 regulates tRNA 2'-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression.
He Q, Yang L, Gao K, Ding P, Chen Q, et al.
Cell Death Dis 2020 Jun 3

Chemosensitivity to HM90822, a novel synthetic IAP antagonist, is determined by p-AKT-inducible XIAP phosphorylation in human pancreatic cancer cells.
Hong SW, Shin JS, Moon JH, Jung SA, Koh DI, et al.
Invest New Drugs 2020 May 27

The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathway.
Hosseini ES, Nikkhah M, Hamidieh AA, Fearnhead HO, Concordet JP, et al.
J Cell Sci 2020 May 27

Tumour Cell Secretome in Chemoresistance and Tumour Recurrence.
Madden EC, Gorman AM, Logue SE, Samali A
Trends Cancer 2020 Jun

Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.
Baek JH, Yun HS, Kim JY, Lee J, Lee YJ, et al.
Cell Death Dis 2020 May 26

Preparation of Biphenyl-Conjugated Bromotyrosine for Inhibition of PD-1/PD-L1 Immune Checkpoint Interactions.
Kim EH, Kawamoto M, Dharmatti R, Kobatake E, Ito Y, et al.
Int J Mol Sci 2020 May 21

Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction during myocardial ischemia.
Sánchez G, Chalmers S, Ahumada X, Montecinos L, Olmedo I, et al.
PLoS One 2020

Inhibition of JAK1/2 can overcome EGFR-TKI resistance in human NSCLC.
Kim DM, Kim MJ, Moon JH, Lee EY, Hong JK, et al.
Biochem Biophys Res Commun 2020 Jun 18

The novel dual BET/HDAC inhibitor TW09 mediates cell death by mitochondrial apoptosis in rhabdomyosarcoma cells.
Laszig S, Boedicker C, Weiser T, Knapp S, Fulda S, et al.
Cancer Lett 2020 Aug 28

Microglia dependent BDNF and proBDNF can impair spatial memory performance during persistent inflammatory pain.
Mohammadi M, Manaheji H, Maghsoudi N, Danyali S, Baniasadi M, et al.
Behav Brain Res 2020 Jul 15

Protective Effects of Fucoidan Isolated from Celluclast-Assisted Extract of <i>Undaria pinnatifida</i> Sporophylls against AAPH-Induced Oxidative Stress In Vitro and In Vivo Zebrafish Model.
Oh JY, Kim EA, Kang SI, Yang HW, Ryu B, et al.
Molecules 2020 May 19

Elevated microRNA-125b inhibits cytotrophoblast invasion and impairs endothelial cell function in preeclampsia.
Li Q, Han Y, Xu P, Yin L, Si Y, et al.
Cell Death Discov 2020

Quercetin Attenuates d-GaLN-Induced L02 Cell Damage by Suppressing Oxidative Stress and Mitochondrial Apoptosis <i>via</i> Inhibition of HMGB1.
Fang P, Liang J, Jiang X, Fang X, Wu M, et al.
Front Pharmacol 2020

Caspase-8-Dependent Inflammatory Responses Are Controlled by Its Adaptor, FADD, and Necroptosis.
Tummers B, Mari L, Guy CS, Heckmann BL, Rodriguez DA, et al.
Immunity 2020 Jun 16

The proteasome activator REGγ accelerates cardiac hypertrophy by declining PP2Acα-SOD2 pathway.
Xie Y, Gao Y, Gao R, Yang W, Dong Z, et al.
Cell Death Differ 2020 May 18

Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma.
Lippmann J, Petri K, Fulda S, Liese J
Transl Oncol 2020 Aug

Microtubule-targeting agents and their impact on cancer treatment.
Čermák V, Dostál V, Jelínek M, Libusová L, Kovář J, et al.
Eur J Cell Biol 2020 May

Fisetin induces apoptosis in uterine leiomyomas through multiple pathways.
Lee JW, Choi HJ, Kim EJ, Hwang WY, Jung MH, et al.
Sci Rep 2020 May 14

PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death.
Lee KP, Liu K, Kim EY, Medina-Puche L, Dong H, et al.
Plant Cell 2020 Jul

Quantitative single-molecule imaging of TNFR1 reveals zafirlukast as antagonist of TNFR1 clustering and TNFα-induced NF-ĸB signaling.
Weinelt N, Karathanasis C, Smith S, Medler J, Malkusch S, et al.
J Leukoc Biol 2020 May 13

FTSJ1 regulates tRNA 2'-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression.
He Q, Yang L, Gao K, Ding P, Chen Q, et al.
Cell Death Dis 2020 May 11

Identification of SYK inhibitor, R406 as a novel senolytic agent.
Cho HJ, Yang EJ, Park JT, Kim JR, Kim EC, et al.
Aging (Albany NY) 2020 May 7

Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts.
H Dehkordi M, Tashakor A, O'Connell E, Fearnhead HO
Cell Death Dis 2020 May 4

Conditioned media from blue light-emitting diode-exposed fibroblasts have an anti-inflammatory effect in vitro.
Oh PS, Kim EM, Lim S, Sohn MH, Jeong HJ, et al.
Lasers Med Sci 2020 May 4

Hepatitis B virus X protein promotes liver cell pyroptosis under oxidative stress through NLRP3 inflammasome activation.
Xie WH, Ding J, Xie XX, Yang XH, Wu XF, et al.
Inflamm Res 2020 Jul

Platelet Membrane-Camouflaged Magnetic Nanoparticles for Ferroptosis-Enhanced Cancer Immunotherapy.
Jiang Q, Wang K, Zhang X, Ouyang B, Liu H, et al.
Small 2020 Jun

Noncanonical Cell Fate Regulation by Bcl-2 Proteins.
Chong SJF, Marchi S, Petroni G, Kroemer G, Galluzzi L, et al.
Trends Cell Biol 2020 Jul

Ribosomal protein S3 is a novel negative regulator of non-homologous end joining repair of DNA double-strand breaks.
Park YJ, Kim TS, Kim EH, Kim HD, Kim J, et al.
FASEB J 2020 Jun

Delivery of MutT homolog 1 inhibitor by functionalized graphene oxide nanoparticles for enhanced chemo-photodynamic therapy triggers cell death in osteosarcoma.
Huang X, Chen J, Wu W, Yang W, Zhong B, et al.
Acta Biomater 2020 Jun

Interleukin-11 regulates the fate of adipose-derived mesenchymal stem cells via STAT3 signalling pathways.
Yang W, Zhang S, Ou T, Jiang H, Jia D, et al.
Cell Prolif 2020 May

Risk Factors for Early Mortality in Patients with Primary Central Nervous System Lymphoma: A Large-Cohort Retrospective Study.
Zhou X, Niu X, Li J, Zhang S, Yang W, et al.
World Neurosurg 2020 Jun

The clearance of dead cells by efferocytosis.
Boada-Romero E, Martinez J, Heckmann BL, Green DR
Nat Rev Mol Cell Biol 2020 Jul

Characterization of the relationship between FLI1 and immune infiltrate level in tumour immune microenvironment for breast cancer.
Wang S, Wang Y, Yu C, Cao Y, Yu Y, et al.
J Cell Mol Med 2020 May

Mammalian Sterile 20-Like Kinase (MST) 1/2: Crucial Players in Nervous and Immune System and Neurological Disorders.
Qi Y, Sun D, Yang W, Xu B, Lv D, et al.
J Mol Biol 2020 May 1

Comment on 'Di-(2-ethylhexyl)-phthalate induces apoptosis via the PPARγ/PTEN/AKT pathway in differentiated human embryonic stem cells'.
Yang C, Wang L, Wang X, Yang W, Xu Y, et al.
Food Chem Toxicol 2020 May

Ionizing Radiation Regulates Vascular Endothelial Growth Factor-A Transcription in Cultured Human Vascular Endothelial Cells Via the PERK/eIF2α/ATF4 Pathway.
Kim EJ, Lee H, Lee YJ, Sonn JK, Lim YB, et al.
Int J Radiat Oncol Biol Phys 2020 Jul 1

Co-inhibition of BET proteins and PI3Kα triggers mitochondrial apoptosis in rhabdomyosarcoma cells.
Boedicker C, Hussong M, Grimm C, Dolgikh N, Meister MT, et al.
Oncogene 2020 May

Cell death through the ages: The ICDS 25th Anniversary Meeting.
Mohammed JN, Gelles JD, Rubio-Patiño C, Serasinghe MN, Trotta AP, et al.
FEBS J 2020 Jun

Microcystin-LR impairs glucose metabolism in pancreatic β cells in vivo and in vitro.
Chen Y, Chen K, Zhou Y, Li X, Mao X, et al.
Toxicol Lett 2020 Jun 15

Classification of analytics, sensorics, and bioanalytics with polyelectrolyte multilayer capsules.
Van der Meeren L, Li J, Parakhonskiy BV, Krysko DV, Skirtach AG, et al.
Anal Bioanal Chem 2020 Aug

Altered distribution and enhanced osteoclastogenesis of mucosal-associated invariant T cells in gouty arthritis.
Cho YN, Jeong HS, Park KJ, Kim HS, Kim EH, et al.
Rheumatology (Oxford) 2020 Aug 1

Corrigendum to "Concurrent MEK and autophagy inhibition is required to restore cell death associated danger-signalling in Vemurafenib-resistant melanoma cells" [Biochem. Pharmacol. 93 (3) (2015) 290-304].
Martin S, Dudek-Perić AM, Maes H, Garg AD, Gabrysiak M, et al.
Biochem Pharmacol 2020 May

Midazolam and isoflurane combination reduces late brain damage in the paraoxon-induced status epilepticus rat model.
Swissa E, Bar-Klein G, Serlin Y, Weissberg I, Kamintsky L, et al.
Neurotoxicology 2020 May

Potential diagnostic value of PD-1 in peripheral blood mononuclear cells of postmenopausal osteoporosis patients.
Cai XP, Zhao Q, Guo ZD, Lin SJ, Chen ZX, et al.
J Clin Lab Anal 2020 Jun

Bifenthrin insecticide promotes oxidative stress and increases inflammatory mediators in human neuroblastoma cells through NF-kappaB pathway.
Gargouri B, Boukholda K, Kumar A, Benazzouz A, Fetoui H, et al.
Toxicol In Vitro 2020 Jun

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.
Lin CC, Mabe NW, Lin YT, Yang WH, Tang X, et al.
Cell Death Differ 2020 Jul

Deoxyribonuclease Reduces Tissue Injury and Improves Survival After Hemorrhagic Shock.
Cagliani J, Yang WL, Brenner M, Wang P
J Surg Res 2020 May

Cantharidic acid induces apoptosis in human nasopharyngeal carcinoma cells through p38-mediated upregulation of caspase activation.
Chen YC, Chen PN, Lin CW, Yang WE, Ho YT, et al.
Environ Toxicol 2020 May

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways.
Dittmann J, Haydn T, Metzger P, Ward GA, Boerries M, et al.
Cell Death Differ 2020 Jun

Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells.
Haydn T, Kehr S, Willmann D, Metzger E, Schüle R, et al.
Int J Cancer 2020 Jun 15

Correction to: HUWE1 controls MCL1 stability to unleash AMBRA1-induced mitophagy.
Strappazzon F, Di Rita A, Peschiaroli A, Leoncini PP, Locatelli F, et al.
Cell Death Differ 2020 May

Impaired NF-κB signalling underlies cyclophilin D-mediated mitochondrial permeability transition pore opening in doxorubicin cardiomyopathy.
Dhingra R, Guberman M, Rabinovich-Nikitin I, Gerstein J, Margulets V, et al.
Cardiovasc Res 2020 May 1

Applied electric fields suppress osimertinib-induced cytotoxicity via inhibiting FOXO3a nuclear translocation through AKT activation.
Li L, Hu C, Lu C, Zhang K, Han R, et al.
Carcinogenesis 2020 Jul 10