Member Publications

CEPO (carbamylated erythropoietin)-Fc protects hippocampal cells in culture against beta amyloid-induced apoptosis: considering Akt/GSK-3β and ERK signaling pathways.
Hooshmandi E, Moosavi M, Katinger H, Sardab S, Ghasemi R, et al.
Mol Biol Rep 2020 Feb 17

Potential diagnostic value of PD-1 in peripheral blood mononuclear cells of postmenopausal osteoporosis patients.
Cai XP, Zhao Q, Guo ZD, Lin SJ, Chen ZX, et al.
J Clin Lab Anal 2020 Feb 17

Bifenthrin insecticide promotes oxidative stress and increases inflammatory mediators in human neuroblastoma cells through NF-kappaB pathway.
Gargouri B, Boukholda K, Kumar A, Benazzouz A, Fetoui H, et al.
Toxicol In Vitro 2020 Feb 13

The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma.
Jeong YK, Oh JY, Yoo JK, Lim SH, Kim EH, et al.
Int J Mol Sci 2020 Jan 29

Abnormal expression of miR-135b-5p in bone tissue of patients with osteoporosis and its role and mechanism in osteoporosis progression.
Chen B, Yang W, Zhao H, Liu K, Deng A, et al.
Exp Ther Med 2020 Feb

A trustworthy CpG nanoplatform for highly safe and efficient cancer photothermal combined immunotherapy.
Ming J, Zhang J, Shi Y, Yang W, Li J, et al.
Nanoscale 2020 Feb 14

ATP13A2 deficiency disrupts lysosomal polyamine export.
van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, et al.
Nature 2020 Feb

Loss of BIM in T cells results in BCL-2 family BH3-member compensation but incomplete cell death sensitivity normalization.
Ludwig LM, Roach LE, Katz SG, LaBelle JL
Apoptosis 2020 Jan 28

Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis.
Yang WH, Chi JT
Mol Cell Oncol 2020

Why not add some SPARKL to your life (and death)!?
Gelles JD, Chipuk JE
Mol Cell Oncol 2020

Predictive factors of death associated with infective endocarditis in adult patients with congenital heart disease.
Ly R, Compain F, Gaye B, Pontnau F, Bouchard M, et al.
Eur Heart J Acute Cardiovasc Care 2020 Jan 28

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence.
Lin CC, Mabe NW, Lin YT, Yang WH, Tang X, et al.
Cell Death Differ 2020 Jan 27

Cancer Cells Employ Nuclear Caspase-8 to Overcome the p53-Dependent G2/M Checkpoint through Cleavage of USP28.
Müller I, Strozyk E, Schindler S, Beissert S, Oo HZ, et al.
Mol Cell 2020 Jan 13

Chidamide induces necroptosis via regulation of c‑FLIPL expression in Jurkat and HUT‑78 cells.
Chi Z, Gao H, Liu H, Wu B, Zhang B, et al.
Mol Med Rep 2020 Feb

STF-62247 and pimozide induce autophagy and autophagic cell death in mouse embryonic fibroblasts.
Kinzler MN, Zielke S, Kardo S, Meyer N, Kögel D, et al.
Sci Rep 2020 Jan 20

Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP.
Hirpara JL, Subramaniam K, Bellot G, Qu J, Seah S, et al.
Redox Biol 2020 Feb

Death by Retrograde Transport: Avoiding the Apoptosis Default.
Green DR
Cell Chem Biol 2019 Dec 19

Facile synthesis of polypyrrole-rhodamine B nanoparticles for self-monitored photothermal therapy of cancer cells.
Wang XH, Chen XQ, Peng HS, Wei XF, Wang XJ, et al.
J Mater Chem B 2020 Feb 7

Detection of Ferroptosis by BODIPY™ 581/591 C11.
Martinez AM, Kim A, Yang WS
Methods Mol Biol 2020

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells.
Karathanasis C, Medler J, Fricke F, Smith S, Malkusch S, et al.
Sci Signal 2020 Jan 14

Deoxyribonuclease Reduces Tissue Injury and Improves Survival After Hemorrhagic Shock.
Cagliani J, Yang WL, Brenner M, Wang P
J Surg Res 2020 Jan 8

An RXLR effector PlAvh142 from Peronophythora litchii triggers plant cell death and contributes to virulence.
Situ J, Jiang L, Fan X, Yang W, Li W, et al.
Mol Plant Pathol 2020 Jan 7

Anti-masculinization induced by aromatase inhibitors in adult female zebrafish.
Chen L, Wang L, Cheng Q, Tu YX, Yang Z, et al.
BMC Genomics 2020 Jan 7

Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β.
Talty A, Deegan S, Ljujic M, Mnich K, Naicker SD, et al.
Cell Death Dis 2020 Jan 6

A novel IFNα-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma.
Ma H, Chang H, Yang W, Lu Y, Hu J, et al.
Mol Cancer 2020 Jan 6

Misfolded proteins bind and activate death receptor 5 to induce apoptosis during unresolved endoplasmic reticulum stress.
Lam M, Marsters SA, Ashkenazi A, Walter P
Elife 2020 Jan 6

Cathepsin K inhibition-induced mitochondrial ROS enhances sensitivity of cancer cells to anti-cancer drugs through USP27x-mediated Bim protein stabilization.
Seo SU, Woo SM, Kim MW, Lee HS, Kim SH, et al.
Redox Biol 2020 Feb

Autophagy, replication stress and DNA synthesis, an intricate relationship.
Cecconi F
Cell Death Differ 2020 Feb

Immunodominant AH1 Antigen-Deficient Necroptotic, but Not Apoptotic, Murine Cancer Cells Induce Antitumor Protection.
Aaes TL, Verschuere H, Kaczmarek A, Heyndrickx L, Wiernicki B, et al.
J Immunol 2020 Feb 15

An inhibitor of apoptosis protein (EsIAP1) from Chinese mitten crab Eriocheir sinensis regulates apoptosis through inhibiting the activity of EsCaspase-3/7-1.
Qu C, Sun J, Xu Q, Lv X, Yang W, et al.
Sci Rep 2019 Dec 31

Quantitation of the ROS production in plasma and radiation treatments of biotargets.
Ji WO, Lee MH, Kim GH, Kim EH
Sci Rep 2019 Dec 27

SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.
Pai SI, Cohen EEW, Lin D, Fountzilas G, Kim ES, et al.
J Transl Med 2019 Dec 26

Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy.
Yang W, Zhang F, Deng H, Lin L, Wang S, et al.
ACS Nano 2020 Jan 28

Exceptional Response of Cryoablation Followed by Pembrolizumab in a Patient with Metastatic Cervical Carcinosarcoma with High Tumor Mutational Burden: A Case Report.
Zhu B, Liu Y, Li J, Diao L, Shao L, et al.
Oncologist 2020 Jan

Primary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson's disease model.
Bae JE, Kang GM, Min SH, Jo DS, Jung YK, et al.
Cell Death Dis 2019 Dec 16

Fiery Cell Death: Pyroptosis in the Central Nervous System.
McKenzie BA, Dixit VM, Power C
Trends Neurosci 2020 Jan

Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine.
Turubanova VD, Balalaeva IV, Mishchenko TA, Catanzaro E, Alzeibak R, et al.
J Immunother Cancer 2019 Dec 16

5-Fluorouracil as a Tumor-Treating Field-Sensitizer in Colon Cancer Therapy.
Lee YJ, Cho JM, Sai S, Oh JY, Park JA, et al.
Cancers (Basel) 2019 Dec 12

Next-generation hypomethylating agent SGI-110 primes acute myeloid leukemia cells to IAP antagonist by activating extrinsic and intrinsic apoptosis pathways.
Dittmann J, Haydn T, Metzger P, Ward GA, Boerries M, et al.
Cell Death Differ 2019 Dec 12

Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-κB and Akt.
Kim JK, Han NR, Park SM, Jegal KH, Jung JY, et al.
Food Chem Toxicol 2020 Jan

G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response.
Yang W, Ru Y, Ren J, Bai J, Wei J, et al.
Cell Death Dis 2019 Dec 11

PD-1H (VISTA)-mediated suppression of autoimmunity in systemic and cutaneous lupus erythematosus.
Han X, Vesely MD, Yang W, Sanmamed MF, Badri T, et al.
Sci Transl Med 2019 Dec 11

p53 Protects Cells from Death at the Heatstroke Threshold Temperature.
Gong L, Zhang Q, Pan X, Chen S, Yang L, et al.
Cell Rep 2019 Dec 10

The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion.
Parra-Flores P, Riquelme JA, Valenzuela-Bustamante P, Leiva-Navarrete S, Vivar R, et al.
Antioxidants (Basel) 2019 Dec 3

T cell-derived interferon-γ programs stem cell death in immune-mediated intestinal damage.
Takashima S, Martin ML, Jansen SA, Fu Y, Bos J, et al.
Sci Immunol 2019 Dec 6

Casein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3.
Lee SY, Kim H, Li CM, Kang J, Najafov A, et al.
Cell Death Dis 2019 Dec 4

Side-by-side comparison of BH3-mimetics identifies MCL-1 as a key therapeutic target in AML.
Ewald L, Dittmann J, Vogler M, Fulda S
Cell Death Dis 2019 Dec 4

Role of Astrocytes in Post-traumatic Epilepsy.
Xu S, Sun Q, Fan J, Jiang Y, Yang W, et al.
Front Neurol 2019

Loss of Oxidation Resistance 1, OXR1, Is Associated with an Autosomal-Recessive Neurological Disease with Cerebellar Atrophy and Lysosomal Dysfunction.
Wang J, Rousseau J, Kim E, Ehresmann S, Cheng YT, et al.
Am J Hum Genet 2019 Dec 5

Brief Normothermic Machine Perfusion Rejuvenates Discarded Human Kidneys.
Hameed AM, Lu DB, Patrick E, Xu B, Hu M, et al.
Transplant Direct 2019 Nov

Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells.
Haydn T, Kehr S, Willmann D, Metzger E, Schüle R, et al.
Int J Cancer 2019 Nov 21

Synergistic Autophagy Effect of miR-212-3p in Zoledronic Acid-Treated In Vitro and Orthotopic In Vivo Models and in Patient-Derived Osteosarcoma Cells.
Oh JY, Kim EH, Lee YJ, Sai S, Lim SH, et al.
Cancers (Basel) 2019 Nov 18

Activity of caspase-8 determines plasticity between cell death pathways.
Newton K, Wickliffe KE, Maltzman A, Dugger DL, Reja R, et al.
Nature 2019 Nov

TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosis.
Baskar R, Fienberg HG, Khair Z, Favaro P, Kimmey S, et al.
Life Sci Alliance 2019 Dec

Bypassing pro-survival and resistance mechanisms of autophagy in EGFR-positive lung cancer cells by targeted delivery of 5FU using theranostic Ag₂S quantum dots.
Duman FD, Akkoc Y, Demirci G, Bavili N, Kiraz A, et al.
J Mater Chem B 2019 Dec 14

ASPP2 inhibits tumor growth by repressing the mevalonate pathway in hepatocellular carcinoma.
Liang B, Chen R, Song S, Wang H, Sun G, et al.
Cell Death Dis 2019 Nov 4

Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse.
Seifert M, Peitzsch C, Gorodetska I, Börner C, Klink B, et al.
PLoS Comput Biol 2019 Nov

Molecular insights on cytochrome c and nucleotide regulation of apoptosome function and its implication in cancer.
Yadav N, Gogada R, O'Malley J, Gundampati RK, Jayanthi S, et al.
Biochim Biophys Acta Mol Cell Res 2020 Jan

A matter of life and death: Molecular, physiological, and environmental regulation of seed longevity.
Zhou W, Chen F, Luo X, Dai Y, Yang Y, et al.
Plant Cell Environ 2020 Feb

A TAZ-ANGPTL4-NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer.
Yang WH, Huang Z, Wu J, Ding CC, Murphy SK, et al.
Mol Cancer Res 2020 Jan

The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
Yu HI, Hsu T, Maruyama EO, Paschen W, Yang W, et al.
Dev Dyn 2020 Feb

Effect of novel porphyrazine photosensitizers on normal and tumor brain cells.
Mishchenko TA, Turubanova VD, Mitroshina EV, Alzeibak R, Peskova NN, et al.
J Biophotonics 2020 Jan

Emerging role of mitophagy in cardiovascular physiology and pathology.
Morales PE, Arias-Durán C, Ávalos-Guajardo Y, Aedo G, Verdejo HE, et al.
Mol Aspects Med 2020 Feb

Rotenone and 3-bromopyruvate toxicity impacts electrical and structural cardiac remodeling in rats.
Zhan C, Liu G, Li J, Li G, Li T, et al.
Toxicol Lett 2020 Jan

Comparative analysis of urban road dust compositions in relation to their potential human health impacts.
Koh B, Kim EA
Environ Pollut 2019 Dec

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.
Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, et al.
Oncogene 2020 Jan

Fisetin improves lead-induced neuroinflammation, apoptosis and synaptic dysfunction in mice associated with the AMPK/SIRT1 and autophagy pathway.
Yang W, Tian ZK, Yang HX, Feng ZJ, Sun JM, et al.
Food Chem Toxicol 2019 Dec

Extracellular vesicles in vascular calcification.
Yang W, Zou B, Hou Y, Yan W, Chen T, et al.
Clin Chim Acta 2019 Dec

Concomitant targeting of Hedgehog signaling and MCL-1 synergistically induces cell death in Hedgehog-driven cancer cells.
Meister MT, Boedicker C, Linder B, Kögel D, Klingebiel T, et al.
Cancer Lett 2019 Nov 28

Palmitic Acid-Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress.
Chu SG, Villalba JA, Liang X, Xiong K, Tsoyi K, et al.
Am J Respir Cell Mol Biol 2019 Dec

Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington's Disease.
Yang W, Xie J, Qiang Q, Li L, Lin X, et al.
Neurosci Bull 2019 Dec

Thioredoxin inhibitor PX-12 induces mitochondria-mediated apoptosis in acute lymphoblastic leukemia cells.
Ehrenfeld V, Fulda S
Biol Chem 2020 Feb 25

Chloroplast-Localized Protoporphyrinogen IX Oxidase1 Is Involved in the Mitotic Cell Cycle in Arabidopsis.
Li J, Zhang F, Li Y, Yang W, Lin R, et al.
Plant Cell Physiol 2019 Nov 1

Targeting ferroptosis in rhabdomyosarcoma cells.
Dächert J, Ehrenfeld V, Habermann K, Dolgikh N, Fulda S, et al.
Int J Cancer 2020 Jan 15

Targeting monocyte-intrinsic enhancer reprogramming improves immunotherapy efficacy in hepatocellular carcinoma.
Liu M, Zhou J, Liu X, Feng Y, Yang W, et al.
Gut 2020 Feb

Protease/antiprotease network in allergy: The role of Staphylococcus aureus protease-like proteins.
Krysko O, Teufelberger A, Van Nevel S, Krysko DV, Bachert C, et al.
Allergy 2019 Nov

Author Correction: Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER-mitochondria communication during the early phase of ER stress.
Bravo-Sagua R, Parra V, Ortiz-Sandoval C, Navarro-Marquez M, Rodríguez AE, et al.
Cell Death Differ 2019 Nov

Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases.
Duvigneau JC, Luís A, Gorman AM, Samali A, Kaltenecker D, et al.
Cytokine 2019 Dec